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Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide : A computational and experimental study. / Arabhalvaei, Vida; Rajaei, Seyedeh Niloufar; Alinaghi, Mohammad Mehdi et al.

In: Scientific Reports, Vol. 16, 34113, 23.06.2026.

Research output: Contribution to journal › Article › peer-review

Harvard

Arabhalvaei, V, Rajaei, SN, Alinaghi, MM, Talebi, M, Dashti, F, Abachi, SF, Khodayar, Z, Jafroodi, AR, Jamalaldin, M, Mehboodi, M, Maleki, MH, Rahimi, A & Baziyar, P 2026, 'Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study', Scientific Reports, vol. 16, 34113. https://doi.org/10.1038/s41598-026-59446-2

APA

Arabhalvaei, V., Rajaei, S. N., Alinaghi, M. M., Talebi, M., Dashti, F., Abachi, S. F., Khodayar, Z., Jafroodi, A. R., Jamalaldin, M., Mehboodi, M., Maleki, M. H., Rahimi, A., & Baziyar, P. (2026). Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study. Scientific Reports, 16, [34113]. https://doi.org/10.1038/s41598-026-59446-2

Vancouver

Arabhalvaei V, Rajaei SN, Alinaghi MM, Talebi M, Dashti F, Abachi SF et al. Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study. Scientific Reports. 2026 Jun 23;16:34113. doi: 10.1038/s41598-026-59446-2

Author

Arabhalvaei, Vida ; Rajaei, Seyedeh Niloufar ; Alinaghi, Mohammad Mehdi et al. / Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide : A computational and experimental study. In: Scientific Reports. 2026 ; Vol. 16.

BibTeX

@article{f0b865bbb85d4e62a600fd23e37e4464,
title = "Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study",
abstract = "Alzheimer{\textquoteright}s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta42 (Aβ42) aggregation, neuroinflammation, and synaptic dysfunction. This study combines computational and experimental approaches to investigate the neuroprotective effects of sodium butyrate (NaB). Differentiated SH-SY5Y neurons were exposed to lipopolysaccharide (LPS) and Aβ₁₋₄₂ to model AD-like conditions, and the potential protective effects of NaB were evaluated. MD simulations indicated that NaB may be associated with destabilization of organized Aβ₄₂ fibrils. Alterations in RMSD, Rg, and SASA values indicated structural instability of Aβ₄₂ fibrils in the presence of NaB. Treatment with NaB (10 and 50 µM) significantly improved cell viability compared to the LPS + Aβ group (p ",
keywords = "Болезнь Альцгеймера, NaB, апоптоз, нейровоспаление, Aβ42, молекулярно-динамическое моделирование, Alzheimer{\textquoteright}s disease, NaB, Apoptosis, Neuroinflammation, Aβ42, MD simulation",
author = "Vida Arabhalvaei and Rajaei, {Seyedeh Niloufar} and Alinaghi, {Mohammad Mehdi} and Mehrshad Talebi and Fatemeh Dashti and Abachi, {Seyedeh Fatemeh} and Zahra Khodayar and Jafroodi, {Arad Ranji} and Mohammad Jamalaldin and Mahtab Mehboodi and Maleki, {Mohammad Hasan} and Atefeh Rahimi and Payam Baziyar",
note = "Arabhalvaei, V., Rajaei, S.N., Alinaghi, M.M. et al. Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study. Sci Rep 16, 34113 (2026). https://doi.org/10.1038/s41598-026-59446-2",
year = "2026",
month = jun,
day = "23",
doi = "10.1038/s41598-026-59446-2",
language = "English",
volume = "16",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide

T2 - A computational and experimental study

AU - Arabhalvaei, Vida

AU - Rajaei, Seyedeh Niloufar

AU - Alinaghi, Mohammad Mehdi

AU - Talebi, Mehrshad

AU - Dashti, Fatemeh

AU - Abachi, Seyedeh Fatemeh

AU - Khodayar, Zahra

AU - Jafroodi, Arad Ranji

AU - Jamalaldin, Mohammad

AU - Mehboodi, Mahtab

AU - Maleki, Mohammad Hasan

AU - Rahimi, Atefeh

AU - Baziyar, Payam

N1 - Arabhalvaei, V., Rajaei, S.N., Alinaghi, M.M. et al. Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study. Sci Rep 16, 34113 (2026). https://doi.org/10.1038/s41598-026-59446-2

PY - 2026/6/23

Y1 - 2026/6/23

N2 - Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta42 (Aβ42) aggregation, neuroinflammation, and synaptic dysfunction. This study combines computational and experimental approaches to investigate the neuroprotective effects of sodium butyrate (NaB). Differentiated SH-SY5Y neurons were exposed to lipopolysaccharide (LPS) and Aβ₁₋₄₂ to model AD-like conditions, and the potential protective effects of NaB were evaluated. MD simulations indicated that NaB may be associated with destabilization of organized Aβ₄₂ fibrils. Alterations in RMSD, Rg, and SASA values indicated structural instability of Aβ₄₂ fibrils in the presence of NaB. Treatment with NaB (10 and 50 µM) significantly improved cell viability compared to the LPS + Aβ group (p 

AB - Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta42 (Aβ42) aggregation, neuroinflammation, and synaptic dysfunction. This study combines computational and experimental approaches to investigate the neuroprotective effects of sodium butyrate (NaB). Differentiated SH-SY5Y neurons were exposed to lipopolysaccharide (LPS) and Aβ₁₋₄₂ to model AD-like conditions, and the potential protective effects of NaB were evaluated. MD simulations indicated that NaB may be associated with destabilization of organized Aβ₄₂ fibrils. Alterations in RMSD, Rg, and SASA values indicated structural instability of Aβ₄₂ fibrils in the presence of NaB. Treatment with NaB (10 and 50 µM) significantly improved cell viability compared to the LPS + Aβ group (p 

KW - Болезнь Альцгеймера

KW - NaB

KW - апоптоз

KW - нейровоспаление

KW - Aβ42

KW - молекулярно-динамическое моделирование

KW - Alzheimer’s disease

KW - NaB

KW - Apoptosis

KW - Neuroinflammation

KW - Aβ42

KW - MD simulation

UR - https://www.mendeley.com/catalogue/8d30406e-15ba-3dfc-bd87-54c9e2af44c8/

UR - https://www.scopus.com/pages/publications/105054837181

U2 - 10.1038/s41598-026-59446-2

DO - 10.1038/s41598-026-59446-2

M3 - Article

C2 - 42336952

VL - 16

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 34113

ER -

ID: 84985003