Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins

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Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins. / Ivanov, Artemii A.; Ukladov, Egor A.; Kremis, Stepan A. et al.

In: Protoplasma, Vol. 259, No. 5, 09.2022, p. 1321-1330.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{e28a2fd654fb477ab167327d7235bf83,

title = "Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins",

abstract = "High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing the positive properties. Previously, we have studied the genotoxic activity of a library of twenty-one 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins and identified modifications that minimize the negative properties. In the current article, we report on an investigation into the cytotoxic activity of the same library. We have aimed to rank the substances in order of the severity of their cytotoxicity and therefore to predict, with the use of statistical processing, the most promising substituents for the furocoumarin scaffold.",

keywords = "Cytotoxicity, Fluorescence, Furocoumarins, Genotoxicity, Peucedanin, Statistical analysis",

author = "Ivanov, {Artemii A.} and Ukladov, {Egor A.} and Kremis, {Stepan A.} and Sharapov, {Sodbo Z.} and Baiborodin, {Sergey I.} and Lipeeva, {Alla V.} and Shults, {Elvira E.} and Golubeva, {Tatiana S.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.",

year = "2022",

month = sep,

doi = "10.1007/s00709-022-01739-0",

language = "English",

volume = "259",

pages = "1321--1330",

journal = "Protoplasma",

issn = "0033-183X",

publisher = "Springer-Verlag GmbH and Co. KG",

number = "5",

}

RIS

TY - JOUR

T1 - Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins

AU - Ivanov, Artemii A.

AU - Ukladov, Egor A.

AU - Kremis, Stepan A.

AU - Sharapov, Sodbo Z.

AU - Baiborodin, Sergey I.

AU - Lipeeva, Alla V.

AU - Shults, Elvira E.

AU - Golubeva, Tatiana S.

PY - 2022/9

Y1 - 2022/9

N2 - High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing the positive properties. Previously, we have studied the genotoxic activity of a library of twenty-one 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins and identified modifications that minimize the negative properties. In the current article, we report on an investigation into the cytotoxic activity of the same library. We have aimed to rank the substances in order of the severity of their cytotoxicity and therefore to predict, with the use of statistical processing, the most promising substituents for the furocoumarin scaffold.

AB - High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing the positive properties. Previously, we have studied the genotoxic activity of a library of twenty-one 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins and identified modifications that minimize the negative properties. In the current article, we report on an investigation into the cytotoxic activity of the same library. We have aimed to rank the substances in order of the severity of their cytotoxicity and therefore to predict, with the use of statistical processing, the most promising substituents for the furocoumarin scaffold.

KW - Cytotoxicity

KW - Fluorescence

KW - Furocoumarins

KW - Genotoxicity

KW - Peucedanin

KW - Statistical analysis

UR - http://www.scopus.com/inward/record.url?scp=85123627706&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/c5c97ef1-6943-3750-b91c-ad0ab180cbab/

U2 - 10.1007/s00709-022-01739-0

DO - 10.1007/s00709-022-01739-0

M3 - Article

C2 - 35080665

AN - SCOPUS:85123627706

VL - 259

SP - 1321

EP - 1330

JO - Protoplasma

JF - Protoplasma

SN - 0033-183X

IS - 5

ER -

ID: 35379338