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Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. / Trofimov, Ivan A.; Yi, Anna P.; Salnikov, Oleg G. et al.

In: Angewandte Chemie - International Edition, Vol. 65, No. 19, e2865398, 26.03.2026.

Research output: Contribution to journal › Article › peer-review

Harvard

Trofimov, IA, Yi, AP, Salnikov, OG, Pravdivtsev, AN, de Maissin, H, Chekmenev, EY, Hövener, JB, Schmidt, AB & Koptyug, IV 2026, 'Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules', Angewandte Chemie - International Edition, vol. 65, no. 19, e2865398. https://doi.org/10.1002/anie.2865398

APA

Trofimov, I. A., Yi, A. P., Salnikov, O. G., Pravdivtsev, A. N., de Maissin, H., Chekmenev, E. Y., Hövener, J. B., Schmidt, A. B., & Koptyug, I. V. (2026). Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. Angewandte Chemie - International Edition, 65(19), [e2865398]. https://doi.org/10.1002/anie.2865398

Vancouver

Trofimov IA, Yi AP, Salnikov OG, Pravdivtsev AN, de Maissin H, Chekmenev EY et al. Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. Angewandte Chemie - International Edition. 2026 Mar 26;65(19):e2865398. doi: 10.1002/anie.2865398

Author

Trofimov, Ivan A. ; Yi, Anna P. ; Salnikov, Oleg G. et al. / Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. In: Angewandte Chemie - International Edition. 2026 ; Vol. 65, No. 19.

BibTeX

@article{5bae1991da3d4c94a2238cf1a1666e56,
title = "Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules",
abstract = "Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond the thermal equilibrium. RASER is of fundamental interest and also possesses several features of possible practical importance, such as very narrow NMR lines and background-free detection. However, so far, the effect was limited to molecules directly polarized by corresponding hyperpolarization techniques. In this work, we found that strongly hyperpolarized allylic compounds transferred polarization via nuclear Overhauser effect (NOE) to other solutes, triggering their RASER. In stark contrast to previous observations, the parahydrogen addition and intermolecular NOE transfer engendered RASER (PAINTER) does not require direct hyperpolarization of the target molecule. This way polarized and detected solutes had 10–20 times narrower lines compared to their classical NMR spectra, providing a useful analysis tool for various molecules beyond standard NMR limitations.",
keywords = "NMR spectroscopy, NOE, RASER, hyperpolarization, parahydrogen, ЯМР-спектроскопия, параводород, RASER, NOE, гиперполяризация",
author = "Trofimov, {Ivan A.} and Yi, {Anna P.} and Salnikov, {Oleg G.} and Pravdivtsev, {Andrey N.} and {de Maissin}, Henri and Chekmenev, {Eduard Y.} and H{\"o}vener, {Jan Bernd} and Schmidt, {Andreas B.} and Koptyug, {Igor V.}",
note = "I. A. Trofimov, A. P. Yi, and O. G. Salnikov, et al., Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. Angewandte Chemie International Edition 65, no. 19 (2026: e2865398, https://doi.org/10.1002/anie.2865398 A.P.Y. and O.G.S. thank the Russian Science Foundation (grant #24-73-10093) for the support of all presented experimental studies. A.P.Y., O.G.S., and I.V.K. thank the Ministry of Science and Higher Educationof the Russian Federation for the access to NMR equipment. I.A.T.,H.d.M., and A.B.S. acknowledge support by the Science Offensive 2024of the Interreg Upper Rhine (Project QUANTUM-PRECISION, #D1-10),the BMBF in the funding program “Quantum Technologies—from BasicResearch to Market” under the project “QuE-MRT” (contract number:13N16448, 13N16450), the German Cancer Consortium (DKTK), theResearch Commission of the University Medical Center Freiburg, B.E.S.T.Fluidsysteme GmbH I Swagelok Stuttgart, and the DFG (#SCHM 3694/1-1,#SCHM 3694/2-1, #SCHM 3694/5-1, #SCHM 3694/6-1, #SFB1479). A.N.P.and J.-B.H. acknowledge funding from the German Federal Ministryof Education and Research (BMBF, 03WIR6208A hyperquant), Heisen-berg DFG grant (565789098), DFG (562203308, 555951950, 527469039,HO-4602/2-2, HO-4602/3, HO-4604/6-1, HO-4604/8-1, Inst 257/747-1,EXC2167/2, FOR5042, TRR287). MOIN CC was founded by a grant fromthe European Regional Development Fund (ERDF) and the Zukunftspro-gramm Wirtschaft of Schleswig-Holstein (Project no. 122-09-053). E.Y.C.thanks the following for funding: National Science Foundation grant:CHE-2404388. E.Y.C. and A.B.S. thank Wayne State University for aPostdoctoral Fellow award.",
year = "2026",
month = mar,
day = "26",
doi = "10.1002/anie.2865398",
language = "English",
volume = "65",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley & Sons Inc.",
number = "19",

}

RIS

TY - JOUR

T1 - Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules

AU - Trofimov, Ivan A.

AU - Yi, Anna P.

AU - Salnikov, Oleg G.

AU - Pravdivtsev, Andrey N.

AU - de Maissin, Henri

AU - Chekmenev, Eduard Y.

AU - Hövener, Jan Bernd

AU - Schmidt, Andreas B.

AU - Koptyug, Igor V.

N1 - I. A. Trofimov, A. P. Yi, and O. G. Salnikov, et al., Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. Angewandte Chemie International Edition 65, no. 19 (2026: e2865398, https://doi.org/10.1002/anie.2865398 A.P.Y. and O.G.S. thank the Russian Science Foundation (grant #24-73-10093) for the support of all presented experimental studies. A.P.Y., O.G.S., and I.V.K. thank the Ministry of Science and Higher Educationof the Russian Federation for the access to NMR equipment. I.A.T.,H.d.M., and A.B.S. acknowledge support by the Science Offensive 2024of the Interreg Upper Rhine (Project QUANTUM-PRECISION, #D1-10),the BMBF in the funding program “Quantum Technologies—from BasicResearch to Market” under the project “QuE-MRT” (contract number:13N16448, 13N16450), the German Cancer Consortium (DKTK), theResearch Commission of the University Medical Center Freiburg, B.E.S.T.Fluidsysteme GmbH I Swagelok Stuttgart, and the DFG (#SCHM 3694/1-1,#SCHM 3694/2-1, #SCHM 3694/5-1, #SCHM 3694/6-1, #SFB1479). A.N.P.and J.-B.H. acknowledge funding from the German Federal Ministryof Education and Research (BMBF, 03WIR6208A hyperquant), Heisen-berg DFG grant (565789098), DFG (562203308, 555951950, 527469039,HO-4602/2-2, HO-4602/3, HO-4604/6-1, HO-4604/8-1, Inst 257/747-1,EXC2167/2, FOR5042, TRR287). MOIN CC was founded by a grant fromthe European Regional Development Fund (ERDF) and the Zukunftspro-gramm Wirtschaft of Schleswig-Holstein (Project no. 122-09-053). E.Y.C.thanks the following for funding: National Science Foundation grant:CHE-2404388. E.Y.C. and A.B.S. thank Wayne State University for aPostdoctoral Fellow award.

PY - 2026/3/26

Y1 - 2026/3/26

N2 - Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond the thermal equilibrium. RASER is of fundamental interest and also possesses several features of possible practical importance, such as very narrow NMR lines and background-free detection. However, so far, the effect was limited to molecules directly polarized by corresponding hyperpolarization techniques. In this work, we found that strongly hyperpolarized allylic compounds transferred polarization via nuclear Overhauser effect (NOE) to other solutes, triggering their RASER. In stark contrast to previous observations, the parahydrogen addition and intermolecular NOE transfer engendered RASER (PAINTER) does not require direct hyperpolarization of the target molecule. This way polarized and detected solutes had 10–20 times narrower lines compared to their classical NMR spectra, providing a useful analysis tool for various molecules beyond standard NMR limitations.

AB - Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond the thermal equilibrium. RASER is of fundamental interest and also possesses several features of possible practical importance, such as very narrow NMR lines and background-free detection. However, so far, the effect was limited to molecules directly polarized by corresponding hyperpolarization techniques. In this work, we found that strongly hyperpolarized allylic compounds transferred polarization via nuclear Overhauser effect (NOE) to other solutes, triggering their RASER. In stark contrast to previous observations, the parahydrogen addition and intermolecular NOE transfer engendered RASER (PAINTER) does not require direct hyperpolarization of the target molecule. This way polarized and detected solutes had 10–20 times narrower lines compared to their classical NMR spectra, providing a useful analysis tool for various molecules beyond standard NMR limitations.

KW - NMR spectroscopy

KW - NOE

KW - RASER

KW - hyperpolarization

KW - parahydrogen

KW - ЯМР-спектроскопия

KW - параводород

KW - RASER

KW - NOE

KW - гиперполяризация

UR - https://www.mendeley.com/catalogue/000bcdd5-822f-3373-9676-ef52935ad481/

UR - https://www.scopus.com/pages/publications/105034101258

U2 - 10.1002/anie.2865398

DO - 10.1002/anie.2865398

M3 - Article

C2 - 41889191

VL - 65

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 19

M1 - e2865398

ER -

ID: 84800351