Research output: Contribution to journal › Article › peer-review
Integrated mathematical models for describing complex biological processes. / Mishchenko, E. L.; Petrovskaya, O. V.; Mishchenko, A. M. et al.
In: Biophysics (Russian Federation), Vol. 62, No. 5, 15, 01.09.2017, p. 778-795.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Integrated mathematical models for describing complex biological processes
AU - Mishchenko, E. L.
AU - Petrovskaya, O. V.
AU - Mishchenko, A. M.
AU - Petrovskiy, E. D.
AU - Ivanisenko, N. V.
AU - Ivanisenko, V. A.
N1 - This work was supported by the Russian Science Foundation (project no. 14-44-00011 Programmed cell death induced via death receptors: identification of molecular mechanisms initiating apoptosis with the use of molecular modeling).
PY - 2017/9/1
Y1 - 2017/9/1
N2 - This review describes integrated mathematical models of processes, such as calcium homeostasis, pathogen–host interaction (with hepatitis C virus as a pathogen), and the response of the human brain to a stimulating event. It is shown that integrated mathematical models provide a deeper insight into the mechanisms and conditions that lead to the development of diseases of different natures (musculoskeletal disorders, viral infections, and various impairments in brain function) and aid identification of the key targets and conditions for a directed effect of new generation drugs, as well as the interpretation of the results of state-of-theart CT imaging.
AB - This review describes integrated mathematical models of processes, such as calcium homeostasis, pathogen–host interaction (with hepatitis C virus as a pathogen), and the response of the human brain to a stimulating event. It is shown that integrated mathematical models provide a deeper insight into the mechanisms and conditions that lead to the development of diseases of different natures (musculoskeletal disorders, viral infections, and various impairments in brain function) and aid identification of the key targets and conditions for a directed effect of new generation drugs, as well as the interpretation of the results of state-of-theart CT imaging.
KW - calcium homeostasis
KW - hepatitis C virus
KW - human brain
KW - mathematical modeling
KW - mechanisms of diseases
KW - stimulating event
KW - therapeutic effects
UR - http://www.scopus.com/inward/record.url?scp=85038414598&partnerID=8YFLogxK
UR - https://elibrary.ru/item.asp?id=35479076
U2 - 10.1134/S0006350917050141
DO - 10.1134/S0006350917050141
M3 - Article
AN - SCOPUS:85038414598
VL - 62
SP - 778
EP - 795
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 5
M1 - 15
ER -
ID: 9645271