Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1

Tdp1 inhibitor, terpenophenols, tyrosyl-DNA phosphodiesterase 1, Usnea barbata, Usneaceae, usnic acid, Phosphoric Diester Hydrolases/drug effects, Escherichia coli, Humans, MCF-7 Cells/drug effects, HEK293 Cells/drug effects, Benzofurans/chemical synthesis, Cell Line, Tumor/drug effects, Microorganisms, Genetically-Modified, Phosphodiesterase Inhibitors/chemistry, Molecular Docking Simulation, REPAIR, BIOLOGICAL EVALUATION, ASSAY, CRYSTAL-STRUCTURE, VANADATE, I INHIBITORS, ANTICANCER, GENE, TDP1, BINDING

ID: 18295205