Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy

Standard

Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy. / Kovaleva, Kseniya; Oleshko, Olga; Yarovaya, Olga et al.

Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference. ed. / Vasiliy Bakulev; Elena Kovaleva; Tatiana Glukhareva; Tatiana Beryozkina; Yuri Schafran; Polina Lyubyakina; Olga Koptyaeva. American Institute of Physics Inc., 2022. 020036 (AIP Conference Proceedings; Vol. 2390).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

Harvard

Kovaleva, K, Oleshko, O, Yarovaya, O , Cheresiz, S, Zakharenko, A, Ponomarev, K, Lavrik, O , Pokrovsky, A & Salakhutdinov, N 2022, Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy. in V Bakulev, E Kovaleva, T Glukhareva, T Beryozkina, Y Schafran, P Lyubyakina & O Koptyaeva (eds), Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference., 020036, AIP Conference Proceedings, vol. 2390, American Institute of Physics Inc., 2020 International Scientific Conference on Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020, Yekaterinburg, Russian Federation, 18.11.2020. https://doi.org/10.1063/5.0069407

APA

Kovaleva, K., Oleshko, O., Yarovaya, O., Cheresiz, S., Zakharenko, A., Ponomarev, K., Lavrik, O., Pokrovsky, A., & Salakhutdinov, N. (2022). Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy. In V. Bakulev, E. Kovaleva, T. Glukhareva, T. Beryozkina, Y. Schafran, P. Lyubyakina, & O. Koptyaeva (Eds.), Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference [020036] (AIP Conference Proceedings; Vol. 2390). American Institute of Physics Inc.. https://doi.org/10.1063/5.0069407

Vancouver

Kovaleva K, Oleshko O, Yarovaya O , Cheresiz S, Zakharenko A, Ponomarev K et al. Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy. In Bakulev V, Kovaleva E, Glukhareva T, Beryozkina T, Schafran Y, Lyubyakina P, Koptyaeva O, editors, Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference. American Institute of Physics Inc. 2022. 020036. (AIP Conference Proceedings). doi: 10.1063/5.0069407

Author

Kovaleva, Kseniya ; Oleshko, Olga ; Yarovaya, Olga et al. / Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy. Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020: Proceedings of the International Scientific Conference. editor / Vasiliy Bakulev ; Elena Kovaleva ; Tatiana Glukhareva ; Tatiana Beryozkina ; Yuri Schafran ; Polina Lyubyakina ; Olga Koptyaeva. American Institute of Physics Inc., 2022. (AIP Conference Proceedings).

BibTeX

@inproceedings{17b9332437f541d0b49b968b4da9f793,

title = "Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy",

abstract = "A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors has been found among resin acid derivatives. Several novel bisureas derived from dehydroabietylamine (DHAm) were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.09 to 0.19 μM. Several compounds demonstrated the enhancement of cytotoxic activity of the alkylating agent, Lomustine, the chemotherapeutic drug used for the glioblastoma (GBM) treatment. The effect has been studied in two GBM cell lines U-87 and SNB19.",

author = "Kseniya Kovaleva and Olga Oleshko and Olga Yarovaya and Sergey Cheresiz and Alexandra Zakharenko and Konstantin Ponomarev and Olga Lavrik and Andrey Pokrovsky and Nariman Salakhutdinov",

note = "Funding Information: This work was supported by a grant from the Russian Science Foundation 19-73-00051 and FSUS-2020-0035. Publisher Copyright: {\textcopyright} 2022 Author(s).; 2020 International Scientific Conference on Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020 ; Conference date: 18-11-2020 Through 21-11-2020",

year = "2022",

month = feb,

day = "4",

doi = "10.1063/5.0069407",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Vasiliy Bakulev and Elena Kovaleva and Tatiana Glukhareva and Tatiana Beryozkina and Yuri Schafran and Polina Lyubyakina and Olga Koptyaeva",

booktitle = "Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020",

}

RIS

TY - GEN

T1 - Inhibition of the DNA repair enzyme TDP1 by the resin acid derivatives as a new way to increase the efficiency of glioblastoma chemotherapy

AU - Kovaleva, Kseniya

AU - Oleshko, Olga

AU - Yarovaya, Olga

AU - Cheresiz, Sergey

AU - Zakharenko, Alexandra

AU - Ponomarev, Konstantin

AU - Lavrik, Olga

AU - Pokrovsky, Andrey

AU - Salakhutdinov, Nariman

PY - 2022/2/4

Y1 - 2022/2/4

N2 - A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors has been found among resin acid derivatives. Several novel bisureas derived from dehydroabietylamine (DHAm) were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.09 to 0.19 μM. Several compounds demonstrated the enhancement of cytotoxic activity of the alkylating agent, Lomustine, the chemotherapeutic drug used for the glioblastoma (GBM) treatment. The effect has been studied in two GBM cell lines U-87 and SNB19.

AB - A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors has been found among resin acid derivatives. Several novel bisureas derived from dehydroabietylamine (DHAm) were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.09 to 0.19 μM. Several compounds demonstrated the enhancement of cytotoxic activity of the alkylating agent, Lomustine, the chemotherapeutic drug used for the glioblastoma (GBM) treatment. The effect has been studied in two GBM cell lines U-87 and SNB19.

UR - http://www.scopus.com/inward/record.url?scp=85125633015&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/36de599e-0c6a-34ab-a1dc-99f014ec6054/

U2 - 10.1063/5.0069407

DO - 10.1063/5.0069407

M3 - Conference contribution

AN - SCOPUS:85125633015

T3 - AIP Conference Proceedings

BT - Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020

A2 - Bakulev, Vasiliy

A2 - Kovaleva, Elena

A2 - Glukhareva, Tatiana

A2 - Beryozkina, Tatiana

A2 - Schafran, Yuri

A2 - Lyubyakina, Polina

A2 - Koptyaeva, Olga

PB - American Institute of Physics Inc.

T2 - 2020 International Scientific Conference on Actual Problems of Organic Chemistry and Biotechnology, OCBT 2020

Y2 - 18 November 2020 through 21 November 2020

ER -

ID: 35611780