Standard

In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells. / Taskaeva, Y. S.; Bgatova, N. P.; Dossymbekova, R. S. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 170, No. 2, 12.2020, p. 246-250.

Research output: Contribution to journal › Article › peer-review

Harvard

Taskaeva, YS, Bgatova, NP, Dossymbekova, RS, Solovieva, AO, Miroshnichenko, SM, Sharipov, KO & Tungushbaeva, ZB 2020, 'In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells', Bulletin of Experimental Biology and Medicine, vol. 170, no. 2, pp. 246-250. https://doi.org/10.1007/s10517-020-05044-9

APA

Taskaeva, Y. S., Bgatova, N. P., Dossymbekova, R. S., Solovieva, A. O., Miroshnichenko, S. M., Sharipov, K. O., & Tungushbaeva, Z. B. (2020). In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells. Bulletin of Experimental Biology and Medicine, 170(2), 246-250. https://doi.org/10.1007/s10517-020-05044-9

Vancouver

Taskaeva YS, Bgatova NP, Dossymbekova RS, Solovieva AO, Miroshnichenko SM, Sharipov KO et al. In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells. Bulletin of Experimental Biology and Medicine. 2020 Dec;170(2):246-250. doi: 10.1007/s10517-020-05044-9

Author

Taskaeva, Y. S. ; Bgatova, N. P. ; Dossymbekova, R. S. et al. / In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells. In: Bulletin of Experimental Biology and Medicine. 2020 ; Vol. 170, No. 2. pp. 246-250.

BibTeX

@article{563af03b1ad442e39f8496fb2865c230,
title = "In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells",
abstract = "We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbonate. Induction of autophagy in HCC-29 cells was detected by transmission electron microscopy and immunofluorescence staining. Thus, lithium carbonate produces an antitumor effect by arresting cell cycle in the G2/M-phase and induction of apoptosis and autophagy in HCC-29 cells, which confirms the lithium potential as a promising drug for the treatment of hepatocellular carcinoma.",
keywords = "apoptosis, autophagy, cell cycle, hepatocellular carcinoma, lithium carbonate (LiCO)",
author = "Taskaeva, {Y. S.} and Bgatova, {N. P.} and Dossymbekova, {R. S.} and Solovieva, {A. O.} and Miroshnichenko, {S. M.} and Sharipov, {K. O.} and Tungushbaeva, {Z. B.}",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1007/s10517-020-05044-9",
language = "English",
volume = "170",
pages = "246--250",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - In Vitro Effects of Lithium Carbonate on Cell Cycle, Apoptosis, and Autophagy in Hepatocellular Carcinoma-29 Cells

AU - Taskaeva, Y. S.

AU - Bgatova, N. P.

AU - Dossymbekova, R. S.

AU - Solovieva, A. O.

AU - Miroshnichenko, S. M.

AU - Sharipov, K. O.

AU - Tungushbaeva, Z. B.

N1 - Publisher Copyright: © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbonate. Induction of autophagy in HCC-29 cells was detected by transmission electron microscopy and immunofluorescence staining. Thus, lithium carbonate produces an antitumor effect by arresting cell cycle in the G2/M-phase and induction of apoptosis and autophagy in HCC-29 cells, which confirms the lithium potential as a promising drug for the treatment of hepatocellular carcinoma.

AB - We studied the effects of lithium carbonate on the cell cycle, apoptosis, and autophagy in hepatocellular carcinoma-29 cells (HCC-29) in vitro. Flow cytofluorometry analysis revealed accumulation of G2/M-phase HCC-29 cells and increase in the number of apoptotic cells in 48 h after administration of 5 mM lithium carbonate. Induction of autophagy in HCC-29 cells was detected by transmission electron microscopy and immunofluorescence staining. Thus, lithium carbonate produces an antitumor effect by arresting cell cycle in the G2/M-phase and induction of apoptosis and autophagy in HCC-29 cells, which confirms the lithium potential as a promising drug for the treatment of hepatocellular carcinoma.

KW - apoptosis

KW - autophagy

KW - cell cycle

KW - hepatocellular carcinoma

KW - lithium carbonate (LiCO)

UR - http://www.scopus.com/inward/record.url?scp=85097010698&partnerID=8YFLogxK

U2 - 10.1007/s10517-020-05044-9

DO - 10.1007/s10517-020-05044-9

M3 - Article

C2 - 33263850

AN - SCOPUS:85097010698

VL - 170

SP - 246

EP - 250

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -

ID: 27120956