TY - JOUR

T1 - IgA nephropathy is associated with Opisthorchis felineus liver fluke infection: Retrospective 5-year analysis of human kidney samples

AU - Kovner, Anna

AU - Kapushchak, Yaroslav

AU - Hadieva, Elena

AU - Persidskij, Mikhail

AU - Pakharukova, Maria

PY - 2025/2/2

Y1 - 2025/2/2

N2 - Objectives: Infection with the fish-borne liver fluke Opisthorchis felineus, which is transmitted through the consumption of raw or undercooked fish, results in serious liver damage in humans. Currently, limited clinical and experimental data reveal kidney damage co-occurring with chronic opisthorchiasis. We conducted a retrospective analysis of kidney autopsy samples over a five-year period (n = 84). The aim of the study was to assess pathomorphological changes in the kidneys and evaluate whether there is an association between IgA nephropathy and liver fluke infection. Methods: Histological analysis, immunohistochemistry, and statistical analysis were performed. Results: In this study, we demonstrated for the first time that chronic O. felineus infection in humans was associated with tubular dystrophy, the accumulation of renal tubular casts, and glomerulosclerosis. The hypertension increases the pathomorphological changes associated with chronic opisthorchiasis. We also detected IgA and the O. felineus total antigen in glomeruli of infected people. Fisher's test showed a significant association between O. felineus infection and IgA nephropathy, as well as between O. felineus infection and glomerulosclerosis. Conclusions: Therefore, the findings of this study highlight the importance of recognising O. felineus infection as a more than hepatobiliary disease and emphasise the need for careful, personalised monitoring of kidney function in infected individuals.

AB - Objectives: Infection with the fish-borne liver fluke Opisthorchis felineus, which is transmitted through the consumption of raw or undercooked fish, results in serious liver damage in humans. Currently, limited clinical and experimental data reveal kidney damage co-occurring with chronic opisthorchiasis. We conducted a retrospective analysis of kidney autopsy samples over a five-year period (n = 84). The aim of the study was to assess pathomorphological changes in the kidneys and evaluate whether there is an association between IgA nephropathy and liver fluke infection. Methods: Histological analysis, immunohistochemistry, and statistical analysis were performed. Results: In this study, we demonstrated for the first time that chronic O. felineus infection in humans was associated with tubular dystrophy, the accumulation of renal tubular casts, and glomerulosclerosis. The hypertension increases the pathomorphological changes associated with chronic opisthorchiasis. We also detected IgA and the O. felineus total antigen in glomeruli of infected people. Fisher's test showed a significant association between O. felineus infection and IgA nephropathy, as well as between O. felineus infection and glomerulosclerosis. Conclusions: Therefore, the findings of this study highlight the importance of recognising O. felineus infection as a more than hepatobiliary disease and emphasise the need for careful, personalised monitoring of kidney function in infected individuals.

KW - IgA

KW - Opisthorchis felineus

KW - glomerular disease

KW - human

KW - nephropathy

KW - Adult

KW - Aged

KW - Animals

KW - Female

KW - Glomerulonephritis, IGA/parasitology

KW - Humans

KW - Kidney/pathology

KW - Male

KW - Middle Aged

KW - Opisthorchiasis/complications

KW - Opisthorchis/isolation & purification

KW - Retrospective Studies

UR - https://www.mendeley.com/catalogue/f9c2dea1-c36d-30b9-86e9-3a4c087f6442/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85216595822&origin=inward&txGid=d1b4a5eab17b679851bf59d8d7962d2c

UR - https://pubmed.ncbi.nlm.nih.gov/39894678/

U2 - 10.1111/tmi.14093

DO - 10.1111/tmi.14093

M3 - Article

C2 - 39894678

VL - 30

SP - 292

EP - 302

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

SN - 1365-3156

IS - 4

ER -