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Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis. / Brown, Samantha; Higham, Thomas; Slon, Viviane et al.

In: Scientific Reports, Vol. 6, 23559, 29.03.2016.

Research output: Contribution to journal › Article › peer-review

Harvard

Brown, S, Higham, T, Slon, V, Paabo, S, Meyer, M, Douka, K, Brock, F, Comeskey, D, Procopio, N, Shunkov, M, Derevianko, A & Buckley, M 2016, 'Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis', Scientific Reports, vol. 6, 23559. https://doi.org/10.1038/srep23559

APA

Brown, S., Higham, T., Slon, V., Paabo, S., Meyer, M., Douka, K., Brock, F., Comeskey, D., Procopio, N., Shunkov, M., Derevianko, A., & Buckley, M. (2016). Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis. Scientific Reports, 6, [23559]. https://doi.org/10.1038/srep23559

Vancouver

Brown S, Higham T, Slon V, Paabo S, Meyer M, Douka K et al. Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis. Scientific Reports. 2016 Mar 29;6:23559. doi: 10.1038/srep23559

Author

Brown, Samantha ; Higham, Thomas ; Slon, Viviane et al. / Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis. In: Scientific Reports. 2016 ; Vol. 6.

BibTeX

@article{aeb2226cd671447f9c4a0503f910af9f,
title = "Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis",
abstract = "DNA sequencing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic. Unfortunately, while many Palaeolithic sites contain large numbers of bones, the majority of these lack the diagnostic features necessary for traditional morphological identification. As a result the recovery of Pleistocene-age human remains is extremely rare. To circumvent this problem we have applied a method of collagen fingerprinting to more than 2000 fragmented bones from the site of Denisova Cave, Russia, in order to facilitate the discovery of human remains. As a result of our analysis a single hominin bone (Denisova 11) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochondrial DNA of the Neandertal type. Subsequent radiocarbon dating revealed the bone to be > 50,000 years old. Here we demonstrate the huge potential collagen fingerprinting has for identifying hominin remains in highly fragmentary archaeological assemblages, improving the resources available for wider studies into human evolution.",
author = "Samantha Brown and Thomas Higham and Viviane Slon and Svante Paabo and Matthias Meyer and Katerina Douka and Fiona Brock and Daniel Comeskey and Noemi Procopio and Michael Shunkov and Anatoly Derevianko and Michael Buckley",
year = "2016",
month = mar,
day = "29",
doi = "10.1038/srep23559",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis

AU - Brown, Samantha

AU - Higham, Thomas

AU - Slon, Viviane

AU - Paabo, Svante

AU - Meyer, Matthias

AU - Douka, Katerina

AU - Brock, Fiona

AU - Comeskey, Daniel

AU - Procopio, Noemi

AU - Shunkov, Michael

AU - Derevianko, Anatoly

AU - Buckley, Michael

PY - 2016/3/29

Y1 - 2016/3/29

N2 - DNA sequencing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic. Unfortunately, while many Palaeolithic sites contain large numbers of bones, the majority of these lack the diagnostic features necessary for traditional morphological identification. As a result the recovery of Pleistocene-age human remains is extremely rare. To circumvent this problem we have applied a method of collagen fingerprinting to more than 2000 fragmented bones from the site of Denisova Cave, Russia, in order to facilitate the discovery of human remains. As a result of our analysis a single hominin bone (Denisova 11) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochondrial DNA of the Neandertal type. Subsequent radiocarbon dating revealed the bone to be > 50,000 years old. Here we demonstrate the huge potential collagen fingerprinting has for identifying hominin remains in highly fragmentary archaeological assemblages, improving the resources available for wider studies into human evolution.

AB - DNA sequencing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic. Unfortunately, while many Palaeolithic sites contain large numbers of bones, the majority of these lack the diagnostic features necessary for traditional morphological identification. As a result the recovery of Pleistocene-age human remains is extremely rare. To circumvent this problem we have applied a method of collagen fingerprinting to more than 2000 fragmented bones from the site of Denisova Cave, Russia, in order to facilitate the discovery of human remains. As a result of our analysis a single hominin bone (Denisova 11) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochondrial DNA of the Neandertal type. Subsequent radiocarbon dating revealed the bone to be > 50,000 years old. Here we demonstrate the huge potential collagen fingerprinting has for identifying hominin remains in highly fragmentary archaeological assemblages, improving the resources available for wider studies into human evolution.

UR - http://www.scopus.com/inward/record.url?scp=84962359833&partnerID=8YFLogxK

U2 - 10.1038/srep23559

DO - 10.1038/srep23559

M3 - Article

C2 - 27020421

AN - SCOPUS:84962359833

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 23559

ER -

ID: 25377375