TY - JOUR

T1 - ICTV Virus Taxonomy Profile: Filoviridae 2024

AU - Biedenkopf, Nadine

AU - Bukreyev, Alexander

AU - Chandran, Kartik

AU - Di Paola, Nicholas

AU - Formenty, Pierre B H

AU - Griffiths, Anthony

AU - Hume, Adam J

AU - Mühlberger, Elke

AU - Netesov, Sergey V

AU - Palacios, Gustavo

AU - Pawęska, Janusz T

AU - Smither, Sophie

AU - Takada, Ayato

AU - Wahl, Victoria

AU - Kuhn, Jens H

N1 - This work was supported in part through the Laulima Government Solutions, LLC, prime contract with the US National Institute of Allergy and Infectious Diseases under contract no. HHSN272201800013C. J.H.K. performed this work as an employee of Tunnell Government Services, a subcontractor of Laulima Government Solutions, LLC, under contract no. HHSN272201800013C. This work was funded under Agreement No. HSHQDC-15-C-00064 awarded to Battelle National Biodefense Institute by the Department of Homeland Security Science and Technology Directorate for the management and operation of the National Biodefense Analysis and Countermeasures Center, a Federally Funded Research and Development Center (V.W.). The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the US Government or its departments or of the institutions and companies affiliated with the authors, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. The full disclaimer is on the Authors page of the full Report.

PY - 2024/2

Y1 - 2024/2

N2 - Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1-20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

AB - Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1-20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

KW - Animals

KW - Humans

KW - Ebolavirus/genetics

KW - Rhabdoviridae/genetics

KW - Phylogeny

KW - Marburgvirus

KW - Genome, Viral

KW - Virus Replication

KW - Mammals/genetics

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85184344457&origin=inward&txGid=d591de6008fb79694c368be2ff386ea8

U2 - 10.1099/jgv.0.001955

DO - 10.1099/jgv.0.001955

M3 - Article

C2 - 38305775

VL - 105

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

IS - 2

M1 - 001955

ER -