Research output: Contribution to journal › Article › peer-review
Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain. / Shevelev, Oleg B.; Seryapina, Alisa A.; Zavjalov, Evgenii L. et al.
In: Phytomedicine, Vol. 41, 01.03.2018, p. 1-6.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain
AU - Shevelev, Oleg B.
AU - Seryapina, Alisa A.
AU - Zavjalov, Evgenii L.
AU - Gerlinskaya, Lyudmila A.
AU - Goryachkovskaya, Tatiana N.
AU - Slynko, Nikolay M.
AU - Kuibida, Leonid V.
AU - Peltek, Sergey E.
AU - Markel, Arcady L.
AU - Moshkin, Mikhail P.
N1 - Publisher Copyright: © 2018 Elsevier GmbH
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Background: As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. Purpose: One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. Study design and methods: To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats. Results: After seven weeks, Reishi therapy reduced blood pressure in experimental animals at a level comparable to that of losartan. Unlike losartan, intragastric Reishi introduction significantly increases cerebral blood flow and affects cerebral cortex metabolic patterns, shifting the balance of inhibitory and excitatory neurotransmitters toward excitation. Conclusion: Changes in cerebral blood flow and ratios of neurometabolites suggests Reishi has a potential nootropic effect.
AB - Background: As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin. Purpose: One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases. Study design and methods: To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats. Results: After seven weeks, Reishi therapy reduced blood pressure in experimental animals at a level comparable to that of losartan. Unlike losartan, intragastric Reishi introduction significantly increases cerebral blood flow and affects cerebral cortex metabolic patterns, shifting the balance of inhibitory and excitatory neurotransmitters toward excitation. Conclusion: Changes in cerebral blood flow and ratios of neurometabolites suggests Reishi has a potential nootropic effect.
KW - Brain metabolites
KW - Hypertension
KW - Reishi
KW - Carotid Arteries/drug effects
KW - Hypertension/diet therapy
KW - Nootropic Agents/pharmacology
KW - Reishi/chemistry
KW - Antihypertensive Agents/administration & dosage
KW - Phytotherapy/methods
KW - Losartan/pharmacology
KW - Male
KW - Rats, Inbred Strains
KW - Animals
KW - Blood Pressure/drug effects
KW - Cerebrovascular Circulation/drug effects
KW - Cerebral Cortex/drug effects
KW - Dietary Supplements
UR - http://www.scopus.com/inward/record.url?scp=85041668822&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2018.01.013
DO - 10.1016/j.phymed.2018.01.013
M3 - Article
C2 - 29519314
AN - SCOPUS:85041668822
VL - 41
SP - 1
EP - 6
JO - Phytomedicine
JF - Phytomedicine
SN - 0944-7113
ER -
ID: 10427457