TY - JOUR

T1 - How Self-Appraisal Is Mediated by the Brain

AU - Knyazev, Gennady G.

AU - Savostyanov, Alexander N.

AU - Bocharov, Andrey V.

AU - Rudych, Pavel D.

N1 - Funding Information: The study was supported by the budgetary funding of SRINM (Theme No. AAAA-A21-121011990039-2) and by the Russian Foundation for Basic Research (RFBR) (Project Nos. 20-013-00404 and No 18-29-13027). AS was also supported by the budgetary funding of ICG SB RAS Theme No. 0259-2021-0009. Publisher Copyright: © Copyright © 2021 Knyazev, Savostyanov, Bocharov and Rudych. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6/29

Y1 - 2021/6/29

N2 - Self-appraisal is a process that leads to the formation of self-esteem, which contributes to subjective well-being and mental health. Neuroimaging studies link self-esteem with the activity of the medial prefrontal cortex (MPFC), right temporoparietal junction (rTPJ), posterior cingulate cortex (PCC), anterior insula (AIns), and dorsolateral prefrontal cortex. It is not known, however, how the process of self-appraisal itself is mediated by the brain and how different nodes of the self-appraisal network interact with each other. In this study, we used multilevel mediation analysis of functional MRI data recorded during the trait adjective judgment task, treating the emotional valence of adjectives as the predictor, behavioral response as the dependent variable, and brain activity as the mediator. The mediation effect was revealed in the rTPJ. Dynamic causal modeling showed that positive self-descriptions trigger communication within the network, with the rTPJ exerting the strongest excitatory output and MPFC receiving the strongest excitatory input. rAIns receives the strongest inhibitory input and sends exclusively inhibitory connections to other regions pointing out to its role in the processing of negative self-descriptions. Analysis of individual differences showed that in some individuals, self-appraisal is mostly driven by the endorsement of positive self-descriptions and is accompanied by increased activation and communication between rTPJ, MPFC, and PCC. In others, self-appraisal is driven by the rejection of negative self-descriptions and is accompanied by increased activation of rAIns and inhibition of PCC and MPFC. Membership of these groups was predicted by different personality variables. This evidence uncovers different mechanisms of positive self-bias, which may contribute to different facets of self-esteem and are associated with different personality profiles.

AB - Self-appraisal is a process that leads to the formation of self-esteem, which contributes to subjective well-being and mental health. Neuroimaging studies link self-esteem with the activity of the medial prefrontal cortex (MPFC), right temporoparietal junction (rTPJ), posterior cingulate cortex (PCC), anterior insula (AIns), and dorsolateral prefrontal cortex. It is not known, however, how the process of self-appraisal itself is mediated by the brain and how different nodes of the self-appraisal network interact with each other. In this study, we used multilevel mediation analysis of functional MRI data recorded during the trait adjective judgment task, treating the emotional valence of adjectives as the predictor, behavioral response as the dependent variable, and brain activity as the mediator. The mediation effect was revealed in the rTPJ. Dynamic causal modeling showed that positive self-descriptions trigger communication within the network, with the rTPJ exerting the strongest excitatory output and MPFC receiving the strongest excitatory input. rAIns receives the strongest inhibitory input and sends exclusively inhibitory connections to other regions pointing out to its role in the processing of negative self-descriptions. Analysis of individual differences showed that in some individuals, self-appraisal is mostly driven by the endorsement of positive self-descriptions and is accompanied by increased activation and communication between rTPJ, MPFC, and PCC. In others, self-appraisal is driven by the rejection of negative self-descriptions and is accompanied by increased activation of rAIns and inhibition of PCC and MPFC. Membership of these groups was predicted by different personality variables. This evidence uncovers different mechanisms of positive self-bias, which may contribute to different facets of self-esteem and are associated with different personality profiles.

KW - DCM

KW - fMRI

KW - multilevel mediation analysis

KW - self-esteem

KW - self-referential processing

KW - trait adjective judgment task

UR - http://www.scopus.com/inward/record.url?scp=85110114000&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2021.700046

DO - 10.3389/fnhum.2021.700046

M3 - Article

C2 - 34267632

AN - SCOPUS:85110114000

VL - 15

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 700046

ER -