Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications

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Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications. / Salnikov, Oleg G.; Svyatova, Alexandra ; Kovtunova, Larisa M. et al.

In: Chemistry - A European Journal, Vol. 27, No. 4, 18.01.2021, p. 1316-1322.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{0fa0507e3faa4b9385c406c46cec3d4c,

title = "Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications",

abstract = "Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach.",

keywords = "diethyl ether, hyperpolarization, imaging agents, NMR spectroscopy, parahydrogen-induced polarization, GASES, PARA-HYDROGEN, NMR SIGNAL ENHANCEMENT, MRI, RELAXATION, PROPANE, LIVED SPIN STATES",

author = "Salnikov, {Oleg G.} and Alexandra Svyatova and Kovtunova, {Larisa M.} and Chukanov, {Nikita V.} and Bukhtiyarov, {Valerii I.} and Kovtunov, {Kirill V.} and Chekmenev, {Eduard Y.} and Koptyug, {Igor V.}",

year = "2021",

month = jan,

day = "18",

doi = "10.1002/chem.202003638",

language = "English",

volume = "27",

pages = "1316--1322",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "4",

}

RIS

TY - JOUR

T1 - Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications

AU - Salnikov, Oleg G.

AU - Svyatova, Alexandra

AU - Kovtunova, Larisa M.

AU - Chukanov, Nikita V.

AU - Bukhtiyarov, Valerii I.

AU - Kovtunov, Kirill V.

AU - Chekmenev, Eduard Y.

AU - Koptyug, Igor V.

PY - 2021/1/18

Y1 - 2021/1/18

N2 - Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach.

AB - Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach.

KW - diethyl ether

KW - hyperpolarization

KW - imaging agents

KW - NMR spectroscopy

KW - parahydrogen-induced polarization

KW - GASES

KW - PARA-HYDROGEN

KW - NMR SIGNAL ENHANCEMENT

KW - MRI

KW - RELAXATION

KW - PROPANE

KW - LIVED SPIN STATES

UR - http://www.scopus.com/inward/record.url?scp=85097444017&partnerID=8YFLogxK

U2 - 10.1002/chem.202003638

DO - 10.1002/chem.202003638

M3 - Article

C2 - 32881102

AN - SCOPUS:85097444017

VL - 27

SP - 1316

EP - 1322

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 4

ER -

ID: 26702790