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GO System, a DNA Repair Pathway to Cope with Oxidative Damage. / Endutkin, A. V.; Zharkov, D. O.

In: Molecular Biology, Vol. 55, No. 2, 03.2021, p. 193-210.

Research output: Contribution to journal › Review article › peer-review

Harvard

Endutkin, AV & Zharkov, DO 2021, 'GO System, a DNA Repair Pathway to Cope with Oxidative Damage', Molecular Biology, vol. 55, no. 2, pp. 193-210. https://doi.org/10.1134/S0026893321020072

APA

Endutkin, A. V., & Zharkov, D. O. (2021). GO System, a DNA Repair Pathway to Cope with Oxidative Damage. Molecular Biology, 55(2), 193-210. https://doi.org/10.1134/S0026893321020072

Vancouver

Endutkin AV, Zharkov DO. GO System, a DNA Repair Pathway to Cope with Oxidative Damage. Molecular Biology. 2021 Mar;55(2):193-210. doi: 10.1134/S0026893321020072

Author

Endutkin, A. V. ; Zharkov, D. O. / GO System, a DNA Repair Pathway to Cope with Oxidative Damage. In: Molecular Biology. 2021 ; Vol. 55, No. 2. pp. 193-210.

BibTeX

@article{036373276ae749f4a5af6ab52762f3ea,
title = "GO System, a DNA Repair Pathway to Cope with Oxidative Damage",
abstract = "The GO system is part of the DNA base excision repair pathway and is required for the error-free repair of 8-oxoguanine (oxoG), one of the most common oxidative DNA lesions. Due to the ability of oxoG to form oxoG:A mispairs, this base is highly mutagenic. Its repair requires the action of two enzymes: 8-oxoguanine DNA glycosylase (Fpg or MutM in bacteria and OGG1 in eukaryotes), which removes oxoG from oxoG:C pairs, and adenine DNA glycosylase (MutY in bacteria and MUTYH in eukaryotes), which removes A from oxoG:A mispairs to prevent mutations. The third enzyme of the system (MutT in bacteria and MTH1 or NUDT1 in eukaryotes) hydrolyzes 8-oxo-2′-deoxyguanosine triphosphate, thus preventing its incorporation into DNA. Recent data point to the proteins of the GO system as promising targets for the therapy of cancer, autoimmune diseases, and bacterial infections. This review highlights the structure and specificity of the GO system in bacteria and eukaryotes and its unique role in mutation avoidance.",
keywords = "8-oxoguanine, DNA damage, DNA glycosylases, DNA repair, mutagenesis, nucleoside triphosphate hydrolases, oxidative stress",
author = "Endutkin, {A. V.} and Zharkov, {D. O.}",
note = "Funding Information: The work was supported by grant no. 19-74-00068 from the Russian Science Foundation (GO systems in bacteria) and partially by grant no. 17-00-00261/17-00-00265 from the Russian Foundation for Basic Research (GO systems in eukaryotes). Publisher Copyright: {\textcopyright} 2021, Pleiades Publishing, Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
doi = "10.1134/S0026893321020072",
language = "English",
volume = "55",
pages = "193--210",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - GO System, a DNA Repair Pathway to Cope with Oxidative Damage

AU - Endutkin, A. V.

AU - Zharkov, D. O.

N1 - Funding Information: The work was supported by grant no. 19-74-00068 from the Russian Science Foundation (GO systems in bacteria) and partially by grant no. 17-00-00261/17-00-00265 from the Russian Foundation for Basic Research (GO systems in eukaryotes). Publisher Copyright: © 2021, Pleiades Publishing, Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - The GO system is part of the DNA base excision repair pathway and is required for the error-free repair of 8-oxoguanine (oxoG), one of the most common oxidative DNA lesions. Due to the ability of oxoG to form oxoG:A mispairs, this base is highly mutagenic. Its repair requires the action of two enzymes: 8-oxoguanine DNA glycosylase (Fpg or MutM in bacteria and OGG1 in eukaryotes), which removes oxoG from oxoG:C pairs, and adenine DNA glycosylase (MutY in bacteria and MUTYH in eukaryotes), which removes A from oxoG:A mispairs to prevent mutations. The third enzyme of the system (MutT in bacteria and MTH1 or NUDT1 in eukaryotes) hydrolyzes 8-oxo-2′-deoxyguanosine triphosphate, thus preventing its incorporation into DNA. Recent data point to the proteins of the GO system as promising targets for the therapy of cancer, autoimmune diseases, and bacterial infections. This review highlights the structure and specificity of the GO system in bacteria and eukaryotes and its unique role in mutation avoidance.

AB - The GO system is part of the DNA base excision repair pathway and is required for the error-free repair of 8-oxoguanine (oxoG), one of the most common oxidative DNA lesions. Due to the ability of oxoG to form oxoG:A mispairs, this base is highly mutagenic. Its repair requires the action of two enzymes: 8-oxoguanine DNA glycosylase (Fpg or MutM in bacteria and OGG1 in eukaryotes), which removes oxoG from oxoG:C pairs, and adenine DNA glycosylase (MutY in bacteria and MUTYH in eukaryotes), which removes A from oxoG:A mispairs to prevent mutations. The third enzyme of the system (MutT in bacteria and MTH1 or NUDT1 in eukaryotes) hydrolyzes 8-oxo-2′-deoxyguanosine triphosphate, thus preventing its incorporation into DNA. Recent data point to the proteins of the GO system as promising targets for the therapy of cancer, autoimmune diseases, and bacterial infections. This review highlights the structure and specificity of the GO system in bacteria and eukaryotes and its unique role in mutation avoidance.

KW - 8-oxoguanine

KW - DNA damage

KW - DNA glycosylases

KW - DNA repair

KW - mutagenesis

KW - nucleoside triphosphate hydrolases

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85105004823&partnerID=8YFLogxK

U2 - 10.1134/S0026893321020072

DO - 10.1134/S0026893321020072

M3 - Review article

AN - SCOPUS:85105004823

VL - 55

SP - 193

EP - 210

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 2

ER -

ID: 28453445