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Genome-wide association study for body weight in cattle populations from Siberia. / Igoshin, A. V.; Yudin, N. S.; Belonogova, N. M. et al.

In: Animal Genetics, Vol. 50, No. 3, 01.06.2019, p. 250-253.

Research output: Contribution to journalArticlepeer-review

Harvard

Igoshin, AV, Yudin, NS, Belonogova, NM & Larkin, DM 2019, 'Genome-wide association study for body weight in cattle populations from Siberia', Animal Genetics, vol. 50, no. 3, pp. 250-253. https://doi.org/10.1111/age.12786

APA

Igoshin, A. V., Yudin, N. S., Belonogova, N. M., & Larkin, D. M. (2019). Genome-wide association study for body weight in cattle populations from Siberia. Animal Genetics, 50(3), 250-253. https://doi.org/10.1111/age.12786

Vancouver

Igoshin AV, Yudin NS, Belonogova NM, Larkin DM. Genome-wide association study for body weight in cattle populations from Siberia. Animal Genetics. 2019 Jun 1;50(3):250-253. doi: 10.1111/age.12786

Author

Igoshin, A. V. ; Yudin, N. S. ; Belonogova, N. M. et al. / Genome-wide association study for body weight in cattle populations from Siberia. In: Animal Genetics. 2019 ; Vol. 50, No. 3. pp. 250-253.

BibTeX

@article{3ea715d890154863bb776ac777e5f1da,
title = "Genome-wide association study for body weight in cattle populations from Siberia",
abstract = "Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.",
keywords = "CCND2, economically important trait, Hereford, LEPTIN, TRAITS, TOOL, Genome-Wide Association Study, Body Weight, Cattle/genetics, Animals, Siberia, Polymorphism, Single Nucleotide, Quantitative Trait Loci",
author = "Igoshin, {A. V.} and Yudin, {N. S.} and Belonogova, {N. M.} and Larkin, {D. M.}",
note = "{\textcopyright} 2019 Stichting International Foundation for Animal Genetics.",
year = "2019",
month = jun,
day = "1",
doi = "10.1111/age.12786",
language = "English",
volume = "50",
pages = "250--253",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Genome-wide association study for body weight in cattle populations from Siberia

AU - Igoshin, A. V.

AU - Yudin, N. S.

AU - Belonogova, N. M.

AU - Larkin, D. M.

N1 - © 2019 Stichting International Foundation for Animal Genetics.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.

AB - Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.

KW - CCND2

KW - economically important trait

KW - Hereford

KW - LEPTIN

KW - TRAITS

KW - TOOL

KW - Genome-Wide Association Study

KW - Body Weight

KW - Cattle/genetics

KW - Animals

KW - Siberia

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

UR - http://www.scopus.com/inward/record.url?scp=85064006174&partnerID=8YFLogxK

U2 - 10.1111/age.12786

DO - 10.1111/age.12786

M3 - Article

C2 - 30957260

AN - SCOPUS:85064006174

VL - 50

SP - 250

EP - 253

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 3

ER -

ID: 19342490