Research output: Contribution to journal › Article › peer-review
Genome-wide association study for body weight in cattle populations from Siberia. / Igoshin, A. V.; Yudin, N. S.; Belonogova, N. M. et al.
In: Animal Genetics, Vol. 50, No. 3, 01.06.2019, p. 250-253.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Genome-wide association study for body weight in cattle populations from Siberia
AU - Igoshin, A. V.
AU - Yudin, N. S.
AU - Belonogova, N. M.
AU - Larkin, D. M.
N1 - © 2019 Stichting International Foundation for Animal Genetics.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.
AB - Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.
KW - CCND2
KW - economically important trait
KW - Hereford
KW - LEPTIN
KW - TRAITS
KW - TOOL
KW - Genome-Wide Association Study
KW - Body Weight
KW - Cattle/genetics
KW - Animals
KW - Siberia
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
UR - http://www.scopus.com/inward/record.url?scp=85064006174&partnerID=8YFLogxK
U2 - 10.1111/age.12786
DO - 10.1111/age.12786
M3 - Article
C2 - 30957260
AN - SCOPUS:85064006174
VL - 50
SP - 250
EP - 253
JO - Animal Genetics
JF - Animal Genetics
SN - 0268-9146
IS - 3
ER -
ID: 19342490