Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations

Standard

Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations. / Igoshin, Alexander V.; Yurchenko, Andrey A.; Belonogova, Nadezhda M. et al.

In: BMC Genetics, Vol. 20, No. Suppl 1, 26, 18.03.2019, p. 26.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{e8131573afe143229c99f7efffa308c1,

title = "Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations",

abstract = "Background: Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers. Results: We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Conclusions: Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.",

keywords = "Adaptation, Body temperature, Cattle, Cold climate, DCMS, GRIA4, GWAS, MSANTD4, Selection, LOCALIZATION, MODEL, HEREFORD CATTLE, GLUTAMATE RECEPTORS, DISEASE, NMDA, PROTEINS, EXPRESSION, HISTORY",

author = "Igoshin, {Alexander V.} and Yurchenko, {Andrey A.} and Belonogova, {Nadezhda M.} and Petrovsky, {Dmitry V.} and Aitnazarov, {Ruslan B.} and Soloshenko, {Vladimir A.} and Yudin, {Nikolay S.} and Larkin, {Denis M.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s).",

year = "2019",

month = mar,

day = "18",

doi = "10.1186/s12863-019-0725-0",

language = "English",

volume = "20",

pages = "26",

journal = "BMC Genetics",

issn = "1471-2156",

publisher = "Springer Nature",

number = "Suppl 1",

}

RIS

TY - JOUR

T1 - Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations

AU - Igoshin, Alexander V.

AU - Yurchenko, Andrey A.

AU - Belonogova, Nadezhda M.

AU - Petrovsky, Dmitry V.

AU - Aitnazarov, Ruslan B.

AU - Soloshenko, Vladimir A.

AU - Yudin, Nikolay S.

AU - Larkin, Denis M.

PY - 2019/3/18

Y1 - 2019/3/18

N2 - Background: Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers. Results: We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Conclusions: Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.

AB - Background: Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers. Results: We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Conclusions: Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.

KW - Adaptation

KW - Body temperature

KW - Cattle

KW - Cold climate

KW - DCMS

KW - GRIA4

KW - GWAS

KW - MSANTD4

KW - Selection

KW - LOCALIZATION

KW - MODEL

KW - HEREFORD CATTLE

KW - GLUTAMATE RECEPTORS

KW - DISEASE

KW - NMDA

KW - PROTEINS

KW - EXPRESSION

KW - HISTORY

UR - http://www.scopus.com/inward/record.url?scp=85063143905&partnerID=8YFLogxK

U2 - 10.1186/s12863-019-0725-0

DO - 10.1186/s12863-019-0725-0

M3 - Article

C2 - 30885142

AN - SCOPUS:85063143905

VL - 20

SP - 26

JO - BMC Genetics

JF - BMC Genetics

SN - 1471-2156

IS - Suppl 1

M1 - 26

ER -

ID: 18949765