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Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. / Manakhov, Andrey D.; Mintseva, Maria Yu; Andreev, Igor A. et al.

In: Scientific Reports, Vol. 10, No. 1, 15876, 01.12.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Manakhov, AD, Mintseva, MY, Andreev, IA, Uralsky, LI, Andreeva, TV, Trapezov, OV & Rogaev, EI 2020, 'Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype', Scientific Reports, vol. 10, no. 1, 15876. https://doi.org/10.1038/s41598-020-72239-5

APA

Manakhov, A. D., Mintseva, M. Y., Andreev, I. A., Uralsky, L. I., Andreeva, T. V., Trapezov, O. V., & Rogaev, E. I. (2020). Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Scientific Reports, 10(1), [15876]. https://doi.org/10.1038/s41598-020-72239-5

Vancouver

Manakhov AD, Mintseva MY, Andreev IA, Uralsky LI, Andreeva TV, Trapezov OV et al. Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. Scientific Reports. 2020 Dec 1;10(1):15876. doi: 10.1038/s41598-020-72239-5

Author

Manakhov, Andrey D. ; Mintseva, Maria Yu ; Andreev, Igor A. et al. / Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

BibTeX

@article{ee8786c355f94fe897c151f51ae3fde0,
title = "Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype",
abstract = "Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.",
keywords = "RAB38",
author = "Manakhov, {Andrey D.} and Mintseva, {Maria Yu} and Andreev, {Igor A.} and Uralsky, {Lev I.} and Andreeva, {Tatiana V.} and Trapezov, {Oleg V.} and Rogaev, {Evgeny I.}",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41598-020-72239-5",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype

AU - Manakhov, Andrey D.

AU - Mintseva, Maria Yu

AU - Andreev, Igor A.

AU - Uralsky, Lev I.

AU - Andreeva, Tatiana V.

AU - Trapezov, Oleg V.

AU - Rogaev, Evgeny I.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.

AB - Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.

KW - RAB38

UR - http://www.scopus.com/inward/record.url?scp=85091654932&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-72239-5

DO - 10.1038/s41598-020-72239-5

M3 - Article

C2 - 32985525

AN - SCOPUS:85091654932

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15876

ER -

ID: 25645887