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Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension. / Redina, O. E.; Devyatkin, V. A.; Ershov, N. I. et al.

In: Russian Journal of Genetics, Vol. 56, No. 2, 02.2020, p. 213-225.

Research output: Contribution to journal › Article › peer-review

Harvard

Redina, OE, Devyatkin, VA, Ershov, NI & Markel, AL 2020, 'Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension', Russian Journal of Genetics, vol. 56, no. 2, pp. 213-225. https://doi.org/10.1134/S1022795420020106

APA

Redina, O. E., Devyatkin, V. A., Ershov, N. I., & Markel, A. L. (2020). Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension. Russian Journal of Genetics, 56(2), 213-225. https://doi.org/10.1134/S1022795420020106

Vancouver

Redina OE, Devyatkin VA, Ershov NI, Markel AL. Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension. Russian Journal of Genetics. 2020 Feb;56(2):213-225. doi: 10.1134/S1022795420020106

Author

Redina, O. E. ; Devyatkin, V. A. ; Ershov, N. I. et al. / Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension. In: Russian Journal of Genetics. 2020 ; Vol. 56, No. 2. pp. 213-225.

BibTeX

@article{014ff4fab353483a972e25444eeb878e,
title = "Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension",
abstract = "The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.",
keywords = "arterial hypertension, genetic heterogeneity, polymorphism, strains of hypertensive rats, OBESITY, VARIANTS, MODELS, DRUG DISCOVERY, DISEASE, BARDET-BIEDL-SYNDROME, GENOME-WIDE ASSOCIATION",
author = "Redina, {O. E.} and Devyatkin, {V. A.} and Ershov, {N. I.} and Markel, {A. L.}",
year = "2020",
month = feb,
doi = "10.1134/S1022795420020106",
language = "English",
volume = "56",
pages = "213--225",
journal = "Russian Journal of Genetics",
issn = "1022-7954",
publisher = "PLEIADES PUBLISHING INC",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension

AU - Redina, O. E.

AU - Devyatkin, V. A.

AU - Ershov, N. I.

AU - Markel, A. L.

PY - 2020/2

Y1 - 2020/2

N2 - The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.

AB - The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.

KW - arterial hypertension

KW - genetic heterogeneity

KW - polymorphism

KW - strains of hypertensive rats

KW - OBESITY

KW - VARIANTS

KW - MODELS

KW - DRUG DISCOVERY

KW - DISEASE

KW - BARDET-BIEDL-SYNDROME

KW - GENOME-WIDE ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85081987047&partnerID=8YFLogxK

U2 - 10.1134/S1022795420020106

DO - 10.1134/S1022795420020106

M3 - Article

AN - SCOPUS:85081987047

VL - 56

SP - 213

EP - 225

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 2

ER -

ID: 23895507