Research output: Contribution to journal › Article › peer-review
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives. / Manuylov, Victor; Chulanov, Vladimir; Bezuglova, Ludmila et al.
In: Viruses, Vol. 14, No. 11, 2465, 07.11.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives
AU - Manuylov, Victor
AU - Chulanov, Vladimir
AU - Bezuglova, Ludmila
AU - Chub, Elena
AU - Karlsen, Anastasia
AU - Kyuregyan, Karen
AU - Ostankova, Yulia
AU - Semenov, Alexander
AU - Osipova, Ludmila
AU - Tallo, Tatjana
AU - Netesova, Irina
AU - Tkachuk, Artem
AU - Gushchin, Vladimir
AU - Netesov, Sergey
AU - Magnius, Lars O.
AU - Norder, Heléne
PY - 2022/11/7
Y1 - 2022/11/7
N2 - A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.
AB - A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.
KW - aboriginal population
KW - genotypes
KW - HBsAg subtypes
KW - hepatitis B virus
KW - molecular epidemiology
KW - Siberia
KW - Siberian natives
KW - subgenotypes
UR - http://www.scopus.com/inward/record.url?scp=85141649068&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/4b7bd312-7604-3665-aa60-1fcbdb5ec054/
U2 - 10.3390/v14112465
DO - 10.3390/v14112465
M3 - Article
C2 - 36366563
AN - SCOPUS:85141649068
VL - 14
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 11
M1 - 2465
ER -
ID: 39328948