Research output: Contribution to journal › Article › peer-review
Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations. / Tambets, Kristiina; Yunusbayev, Bayazit; Hudjashov, Georgi et al.
In: Genome Biology, Vol. 19, No. 1, 139, 21.09.2018, p. 139.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations
AU - Tambets, Kristiina
AU - Yunusbayev, Bayazit
AU - Hudjashov, Georgi
AU - Ilumäe, Anne Mai
AU - Rootsi, Siiri
AU - Honkola, Terhi
AU - Vesakoski, Outi
AU - Atkinson, Quentin
AU - Skoglund, Pontus
AU - Kushniarevich, Alena
AU - Litvinov, Sergey
AU - Reidla, Maere
AU - Metspalu, Ene
AU - Saag, Lehti
AU - Rantanen, Timo
AU - Karmin, Monika
AU - Parik, Jüri
AU - Zhadanov, Sergey I.
AU - Gubina, Marina
AU - Damba, Larisa D.
AU - Bermisheva, Marina
AU - Reisberg, Tuuli
AU - Dibirova, Khadizhat
AU - Evseeva, Irina
AU - Nelis, Mari
AU - Klovins, Janis
AU - Metspalu, Andres
AU - Esko, Tõnu
AU - Balanovsky, Oleg
AU - Balanovska, Elena
AU - Khusnutdinova, Elza K.
AU - Osipova, Ludmila P.
AU - Voevoda, Mikhail
AU - Villems, Richard
AU - Kivisild, Toomas
AU - Metspalu, Mait
N1 - Publisher Copyright: © 2018 The Author(s).
PY - 2018/9/21
Y1 - 2018/9/21
N2 - Background: The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools. While the maternal lineages reflect by and large the geographic background of a given Uralic-speaking population, the frequency of Y chromosomes of Eastern Eurasian origin is distinctively high among European Uralic speakers. The autosomal variation of Uralic speakers, however, has not yet been studied comprehensively. Results: Here, we present a genome-wide analysis of 15 Uralic-speaking populations which cover all main groups of the linguistic family. We show that contemporary Uralic speakers are genetically very similar to their local geographical neighbours. However, when studying relationships among geographically distant populations, we find that most of the Uralic speakers and some of their neighbours share a genetic component of possibly Siberian origin. Additionally, we show that most Uralic speakers share significantly more genomic segments identity-by-descent with each other than with geographically equidistant speakers of other languages. We find that correlated genome-wide genetic and lexical distances among Uralic speakers suggest co-dispersion of genes and languages. Yet, we do not find long-range genetic ties between Estonians and Hungarians with their linguistic sisters that would distinguish them from their non-Uralic-speaking neighbours. Conclusions: We show that most Uralic speakers share a distinct ancestry component of likely Siberian origin, which suggests that the spread of Uralic languages involved at least some demic component.
AB - Background: The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools. While the maternal lineages reflect by and large the geographic background of a given Uralic-speaking population, the frequency of Y chromosomes of Eastern Eurasian origin is distinctively high among European Uralic speakers. The autosomal variation of Uralic speakers, however, has not yet been studied comprehensively. Results: Here, we present a genome-wide analysis of 15 Uralic-speaking populations which cover all main groups of the linguistic family. We show that contemporary Uralic speakers are genetically very similar to their local geographical neighbours. However, when studying relationships among geographically distant populations, we find that most of the Uralic speakers and some of their neighbours share a genetic component of possibly Siberian origin. Additionally, we show that most Uralic speakers share significantly more genomic segments identity-by-descent with each other than with geographically equidistant speakers of other languages. We find that correlated genome-wide genetic and lexical distances among Uralic speakers suggest co-dispersion of genes and languages. Yet, we do not find long-range genetic ties between Estonians and Hungarians with their linguistic sisters that would distinguish them from their non-Uralic-speaking neighbours. Conclusions: We show that most Uralic speakers share a distinct ancestry component of likely Siberian origin, which suggests that the spread of Uralic languages involved at least some demic component.
KW - Genome-wide analysis
KW - Haplotype analysis
KW - IBD-segments
KW - Population genetics
KW - Uralic languages
KW - European Continental Ancestry Group/genetics
KW - Demography
KW - Genes
KW - Humans
KW - Genetic Variation
KW - Asian Continental Ancestry Group/genetics
KW - Linguistics
KW - Genome, Human
KW - Population Dynamics
KW - REGRESSION
KW - WEST
KW - PATTERNS
KW - ADMIXTURE
KW - INFERENCE
KW - MITOCHONDRIAL-DNA
KW - ANCESTRY
KW - CHROMOSOME HAPLOGROUP-N
KW - DIVERSITY
KW - SELECTION
UR - http://www.scopus.com/inward/record.url?scp=85053601969&partnerID=8YFLogxK
U2 - 10.1186/s13059-018-1522-1
DO - 10.1186/s13059-018-1522-1
M3 - Article
C2 - 30241495
AN - SCOPUS:85053601969
VL - 19
SP - 139
JO - Genome Biology
JF - Genome Biology
SN - 1474-7596
IS - 1
M1 - 139
ER -
ID: 16632522