TY - JOUR

T1 - Genes related to the white face colour pattern in eight Russian cattle breeds

AU - Yudin, N. S.

AU - Belonogova, N. M.

AU - Larkin, D. M.

N1 - Publisher Copyright: © Authors, 2018.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - One of the major effects of domestication is change of animal coat colour to up to complete white colour of the whole body. it is possible that white colour of livestock animals had aesthetic significance for humans as well. the first step towards detection of genes and mutations controlling white colouring in animals is the genome-wide association studies. these studies, however, have not been done for the cattle breeds native to the russian Federation. the aim of this study was therefore to identify genomic intervals and candidate genes that could be responsible for white face colouring in eight russian cattle breeds. the data on genome-wide genotyping of 131,709 high-quality single nucleotide polymorphisms (SnPs) on 148 animas have been used in the program eMMaX. association analysis has been performed using two related phenotypes: A) the white face with the rest of the body of any colour and b) white face with the rest of the body of different (non-white) colour. in the first case, the only statistically significant marker found was the SnP BovineHD0500019319 located on cattle chromosome (Bta) 5. the same SnP was the most significant within the cluster of three SnPs on Bta5: 68,803,879–69,365,854 associated also with the second phenotype. Five genes were found within this interval in the cattle genome, out of which the most likely functional candidate was SLC41A2, with the SnP BovineHD0500019319 found within its in-tronic sequence. SLC41A2 encodes a magnesium transporter protein. However, the function of this gene is not well established. other members of this gene family are the key genes controlling differences in human skin and animal coat colour. additional significant association signals with the second phenotype have been detected in Bta 1–4, 6–15, 18, 19, 24, 27, and 29. overall, 37 genomic intervals have been detected associated with white face colouring in eight russian native cattle breeds.

AB - One of the major effects of domestication is change of animal coat colour to up to complete white colour of the whole body. it is possible that white colour of livestock animals had aesthetic significance for humans as well. the first step towards detection of genes and mutations controlling white colouring in animals is the genome-wide association studies. these studies, however, have not been done for the cattle breeds native to the russian Federation. the aim of this study was therefore to identify genomic intervals and candidate genes that could be responsible for white face colouring in eight russian cattle breeds. the data on genome-wide genotyping of 131,709 high-quality single nucleotide polymorphisms (SnPs) on 148 animas have been used in the program eMMaX. association analysis has been performed using two related phenotypes: A) the white face with the rest of the body of any colour and b) white face with the rest of the body of different (non-white) colour. in the first case, the only statistically significant marker found was the SnP BovineHD0500019319 located on cattle chromosome (Bta) 5. the same SnP was the most significant within the cluster of three SnPs on Bta5: 68,803,879–69,365,854 associated also with the second phenotype. Five genes were found within this interval in the cattle genome, out of which the most likely functional candidate was SLC41A2, with the SnP BovineHD0500019319 found within its in-tronic sequence. SLC41A2 encodes a magnesium transporter protein. However, the function of this gene is not well established. other members of this gene family are the key genes controlling differences in human skin and animal coat colour. additional significant association signals with the second phenotype have been detected in Bta 1–4, 6–15, 18, 19, 24, 27, and 29. overall, 37 genomic intervals have been detected associated with white face colouring in eight russian native cattle breeds.

KW - Breed

KW - Cattle

KW - Colouring

KW - Domestication

KW - Genome-wide association studies

KW - Native populations

KW - SLC41A2

KW - White face

KW - HUMAN SOLUTE CARRIER

KW - DOMESTICATION

KW - DISSECTION

KW - domestication

KW - SCAN

KW - MUTATIONS

KW - colouring

KW - PIGMENTATION

KW - white face

KW - GENOME-WIDE ASSOCIATION

KW - BELT PATTERN

KW - cattle

KW - breed

KW - COAT COLOR

KW - native populations

KW - genome-wide association studies

KW - SLC45A2 GENE

UR - http://www.scopus.com/inward/record.url?scp=85045907436&partnerID=8YFLogxK

U2 - 10.18699/VJ18.350

DO - 10.18699/VJ18.350

M3 - Article

AN - SCOPUS:85045907436

VL - 22

SP - 217

EP - 223

JO - Вавиловский журнал генетики и селекции

JF - Вавиловский журнал генетики и селекции

SN - 2500-0462

IS - 2

ER -