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Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats. / Fedoseeva, L. A.; Smolenskaya, S. E.; Markel, A. L. et al.

In: Molecular Biology, Vol. 57, No. 2, 04.2023, p. 346-355.

Research output: Contribution to journal › Article › peer-review

Harvard

Fedoseeva, LA, Smolenskaya, SE, Markel, AL & Redina, OE 2023, 'Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats', Molecular Biology, vol. 57, no. 2, pp. 346-355. https://doi.org/10.1134/S0026893323020073

APA

Fedoseeva, L. A., Smolenskaya, S. E., Markel, A. L., & Redina, O. E. (2023). Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats. Molecular Biology, 57(2), 346-355. https://doi.org/10.1134/S0026893323020073

Vancouver

Fedoseeva LA, Smolenskaya SE, Markel AL, Redina OE. Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats. Molecular Biology. 2023 Apr;57(2):346-355. doi: 10.1134/S0026893323020073

Author

Fedoseeva, L. A. ; Smolenskaya, S. E. ; Markel, A. L. et al. / Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats. In: Molecular Biology. 2023 ; Vol. 57, No. 2. pp. 346-355.

BibTeX

@article{200cf4d525db4ec2914292906a8bb5d4,
title = "Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats",
abstract = "Inherited stress-induced arterial hypertension (ISIAH) rats are characterized by increased stress reactivity of the hypothalamic–pituitary–adrenal and sympathoadrenal systems. The genetic basis of increased susceptibility to stress was studied in hypertensive ISIAH rats. Adrenal transcriptomes were sequenced in hypertensive ISIAH and normotensive WAG rats, and nine differentially expressed genes (DEGs) were found in the X-chromosome locus that was previously associated with mild emotional stress-induced increases in blood pressure and plasma corticosterone and an increased adrenal weight in ISIAH rats. An analysis of the functions performed by DEG-encoded proteins suggested the Sms (spermine synthase) gene to be the most likely candidate gene in the X-chromosome locus associated with an elevated stress susceptibility in ISIAH rats.",
keywords = "ISIAH rats, RNA-Seq, adrenal, hypertension, stress",
author = "Fedoseeva, {L. A.} and Smolenskaya, {S. E.} and Markel, {A. L.} and Redina, {O. E.}",
note = "This work was supported by the Russian Science Foundation (project no. 22-14-00082). Публикация для корректировки.",
year = "2023",
month = apr,
doi = "10.1134/S0026893323020073",
language = "English",
volume = "57",
pages = "346--355",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats

AU - Fedoseeva, L. A.

AU - Smolenskaya, S. E.

AU - Markel, A. L.

AU - Redina, O. E.

N1 - This work was supported by the Russian Science Foundation (project no. 22-14-00082). Публикация для корректировки.

PY - 2023/4

Y1 - 2023/4

N2 - Inherited stress-induced arterial hypertension (ISIAH) rats are characterized by increased stress reactivity of the hypothalamic–pituitary–adrenal and sympathoadrenal systems. The genetic basis of increased susceptibility to stress was studied in hypertensive ISIAH rats. Adrenal transcriptomes were sequenced in hypertensive ISIAH and normotensive WAG rats, and nine differentially expressed genes (DEGs) were found in the X-chromosome locus that was previously associated with mild emotional stress-induced increases in blood pressure and plasma corticosterone and an increased adrenal weight in ISIAH rats. An analysis of the functions performed by DEG-encoded proteins suggested the Sms (spermine synthase) gene to be the most likely candidate gene in the X-chromosome locus associated with an elevated stress susceptibility in ISIAH rats.

AB - Inherited stress-induced arterial hypertension (ISIAH) rats are characterized by increased stress reactivity of the hypothalamic–pituitary–adrenal and sympathoadrenal systems. The genetic basis of increased susceptibility to stress was studied in hypertensive ISIAH rats. Adrenal transcriptomes were sequenced in hypertensive ISIAH and normotensive WAG rats, and nine differentially expressed genes (DEGs) were found in the X-chromosome locus that was previously associated with mild emotional stress-induced increases in blood pressure and plasma corticosterone and an increased adrenal weight in ISIAH rats. An analysis of the functions performed by DEG-encoded proteins suggested the Sms (spermine synthase) gene to be the most likely candidate gene in the X-chromosome locus associated with an elevated stress susceptibility in ISIAH rats.

KW - ISIAH rats

KW - RNA-Seq

KW - adrenal

KW - hypertension

KW - stress

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85156086352&origin=inward&txGid=1dc96340619f4b818e73720ced1e2a77

UR - https://www.mendeley.com/catalogue/d4b9e20d-c82d-390a-a2d0-edcea34e9063/

U2 - 10.1134/S0026893323020073

DO - 10.1134/S0026893323020073

M3 - Article

VL - 57

SP - 346

EP - 355

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 2

ER -

ID: 59649546