Generation of two clonal iPSC lines, ICGi019-A and ICGi019-B, by reprogramming peripheral blood mononuclear cells of a patient suffering from hypertrophic cardiomyopathy and carrying a heterozygous p.M659I mutation in MYH7

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Generation of two clonal iPSC lines, ICGi019-A and ICGi019-B, by reprogramming peripheral blood mononuclear cells of a patient suffering from hypertrophic cardiomyopathy and carrying a heterozygous p.M659I mutation in MYH7. / Dementyeva, E. V.; Kovalenko, V. R.; Zhiven, M. K. et al.

In: Stem Cell Research, Vol. 46, 101840, 07.2020.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{77313432dbd24933ba971ae866501a5f,

title = "Generation of two clonal iPSC lines, ICGi019-A and ICGi019-B, by reprogramming peripheral blood mononuclear cells of a patient suffering from hypertrophic cardiomyopathy and carrying a heterozygous p.M659I mutation in MYH7",

abstract = "Hypertrophic cardiomyopathy (HCM) is one of the most frequent cardiovascular diseases but no methods to prevent its progression have been developed. Cardiomyocytes derived from patient-specific induced pluripotent stem cells can become a platform to study pathogenesis of the disease and to search for more effective therapy methods. We generated two iPSC lines from peripheral blood mononuclear cells of an HCM patient with heterozygous p.M659I mutation in MYH7 using episomal vectors. The iPSC lines expressed pluripotency markers, demonstrated ability to spontaneously differentiate into derivatives of three germ layers, and retained the mutation.",

keywords = "PLURIPOTENT STEM-CELLS",

author = "Dementyeva, {E. V.} and Kovalenko, {V. R.} and Zhiven, {M. K.} and Ustyantseva, {E. I.} and Kretov, {E. I.} and Vyatkin, {Yu V.} and Zakian, {S. M.}",

year = "2020",

month = jul,

doi = "10.1016/j.scr.2020.101840",

language = "English",

volume = "46",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Generation of two clonal iPSC lines, ICGi019-A and ICGi019-B, by reprogramming peripheral blood mononuclear cells of a patient suffering from hypertrophic cardiomyopathy and carrying a heterozygous p.M659I mutation in MYH7

AU - Dementyeva, E. V.

AU - Kovalenko, V. R.

AU - Zhiven, M. K.

AU - Ustyantseva, E. I.

AU - Kretov, E. I.

AU - Vyatkin, Yu V.

AU - Zakian, S. M.

PY - 2020/7

Y1 - 2020/7

N2 - Hypertrophic cardiomyopathy (HCM) is one of the most frequent cardiovascular diseases but no methods to prevent its progression have been developed. Cardiomyocytes derived from patient-specific induced pluripotent stem cells can become a platform to study pathogenesis of the disease and to search for more effective therapy methods. We generated two iPSC lines from peripheral blood mononuclear cells of an HCM patient with heterozygous p.M659I mutation in MYH7 using episomal vectors. The iPSC lines expressed pluripotency markers, demonstrated ability to spontaneously differentiate into derivatives of three germ layers, and retained the mutation.

AB - Hypertrophic cardiomyopathy (HCM) is one of the most frequent cardiovascular diseases but no methods to prevent its progression have been developed. Cardiomyocytes derived from patient-specific induced pluripotent stem cells can become a platform to study pathogenesis of the disease and to search for more effective therapy methods. We generated two iPSC lines from peripheral blood mononuclear cells of an HCM patient with heterozygous p.M659I mutation in MYH7 using episomal vectors. The iPSC lines expressed pluripotency markers, demonstrated ability to spontaneously differentiate into derivatives of three germ layers, and retained the mutation.

KW - PLURIPOTENT STEM-CELLS

UR - http://www.scopus.com/inward/record.url?scp=85084523573&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2020.101840

DO - 10.1016/j.scr.2020.101840

M3 - Article

C2 - 32422568

AN - SCOPUS:85084523573

VL - 46

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 101840

ER -

ID: 24280678