Research output: Contribution to journal › Article › peer-review
Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan. / Dubovskaia, Polina I.; Саейди, Арсалан ; Pronchenko, Anna A. et al.
In: Eurasian Journal of Chemistry, 06.2025.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan
AU - Dubovskaia, Polina I.
AU - Саейди, Арсалан
AU - Pronchenko, Anna A.
AU - Drannikova, Anastasiia I.
AU - Lukoyanov, Ivan A.
AU - Aripova, Farida K.
AU - Savenko, Mariia E.
AU - Veretennikova, Elizaveta A.
AU - Pestov, Alexander V.
AU - Litvinova, Ekaterina A.
AU - Drannikov, Aleksandr A.
N1 - This research was supported by the “Priority-2030” program at Novosibirsk State Technical University (project No. SP-3 Zh-5/1).
PY - 2025/6
Y1 - 2025/6
N2 - The applicabilityof native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, car-boxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer proper-ties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50°C, 1.07–1.12 at 60°C and 1.16–1.32 at 70°C.Porosity measurements indicated pore sizes ranging from 50 to 200 μm in all samples; however, total porosity varied significantly, reaching a max-imum of 15% at 70°C and decreasing to 4–10% at lower temperatures. N-CEC exhibited pH-dependent swelling, with minimal expansion (100–150%) at low pH and a 2–3-fold increase at pH>7, which was at-tributed to COO⁻group formation. These findings position N-CEC as a promising material for pH-responsive applications.
AB - The applicabilityof native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, car-boxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer proper-ties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50°C, 1.07–1.12 at 60°C and 1.16–1.32 at 70°C.Porosity measurements indicated pore sizes ranging from 50 to 200 μm in all samples; however, total porosity varied significantly, reaching a max-imum of 15% at 70°C and decreasing to 4–10% at lower temperatures. N-CEC exhibited pH-dependent swelling, with minimal expansion (100–150%) at low pH and a 2–3-fold increase at pH>7, which was at-tributed to COO⁻group formation. These findings position N-CEC as a promising material for pH-responsive applications.
U2 - 10.31489/2959-0663/2-25-6
DO - 10.31489/2959-0663/2-25-6
M3 - Article
JO - Eurasian Journal of Chemistry
JF - Eurasian Journal of Chemistry
SN - 2959-0663
ER -
ID: 67470870