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Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan. / Dubovskaia, Polina I.; Саейди, Арсалан ; Pronchenko, Anna A. et al.

In: Eurasian Journal of Chemistry, 06.2025.

Research output: Contribution to journalArticlepeer-review

Harvard

Dubovskaia, PI, Саейди, А, Pronchenko, AA, Drannikova, AI, Lukoyanov, IA, Aripova, FK, Savenko, ME, Veretennikova, EA, Pestov, AV, Litvinova, EA & Drannikov, AA 2025, 'Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan', Eurasian Journal of Chemistry. https://doi.org/10.31489/2959-0663/2-25-6

APA

Dubovskaia, P. I., Саейди, А., Pronchenko, A. A., Drannikova, A. I., Lukoyanov, I. A., Aripova, F. K., Savenko, M. E., Veretennikova, E. A., Pestov, A. V., Litvinova, E. A., & Drannikov, A. A. (2025). Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan. Eurasian Journal of Chemistry. https://doi.org/10.31489/2959-0663/2-25-6

Vancouver

Dubovskaia PI, Саейди А, Pronchenko AA, Drannikova AI, Lukoyanov IA, Aripova FK et al. Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan. Eurasian Journal of Chemistry. 2025 Jun. doi: 10.31489/2959-0663/2-25-6

Author

Dubovskaia, Polina I. ; Саейди, Арсалан ; Pronchenko, Anna A. et al. / Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan. In: Eurasian Journal of Chemistry. 2025.

BibTeX

@article{9990ad85ddf842d29f22050d02775f31,
title = "Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan",
abstract = "The applicabilityof native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, car-boxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer proper-ties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50°C, 1.07–1.12 at 60°C and 1.16–1.32 at 70°C.Porosity measurements indicated pore sizes ranging from 50 to 200 μm in all samples; however, total porosity varied significantly, reaching a max-imum of 15% at 70°C and decreasing to 4–10% at lower temperatures. N-CEC exhibited pH-dependent swelling, with minimal expansion (100–150%) at low pH and a 2–3-fold increase at pH>7, which was at-tributed to COO⁻group formation. These findings position N-CEC as a promising material for pH-responsive applications.",
author = "Dubovskaia, {Polina I.} and Арсалан Саейди and Pronchenko, {Anna A.} and Drannikova, {Anastasiia I.} and Lukoyanov, {Ivan A.} and Aripova, {Farida K.} and Savenko, {Mariia E.} and Veretennikova, {Elizaveta A.} and Pestov, {Alexander V.} and Litvinova, {Ekaterina A.} and Drannikov, {Aleksandr A.}",
note = "This research was supported by the “Priority-2030” program at Novosibirsk State Technical University (project No. SP-3 Zh-5/1).",
year = "2025",
month = jun,
doi = "10.31489/2959-0663/2-25-6",
language = "English",
journal = "Eurasian Journal of Chemistry",
issn = "2959-0663",
publisher = "E.A. Buketov Karaganda University Publish house",

}

RIS

TY - JOUR

T1 - Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan

AU - Dubovskaia, Polina I.

AU - Саейди, Арсалан

AU - Pronchenko, Anna A.

AU - Drannikova, Anastasiia I.

AU - Lukoyanov, Ivan A.

AU - Aripova, Farida K.

AU - Savenko, Mariia E.

AU - Veretennikova, Elizaveta A.

AU - Pestov, Alexander V.

AU - Litvinova, Ekaterina A.

AU - Drannikov, Aleksandr A.

N1 - This research was supported by the “Priority-2030” program at Novosibirsk State Technical University (project No. SP-3 Zh-5/1).

PY - 2025/6

Y1 - 2025/6

N2 - The applicabilityof native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, car-boxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer proper-ties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50°C, 1.07–1.12 at 60°C and 1.16–1.32 at 70°C.Porosity measurements indicated pore sizes ranging from 50 to 200 μm in all samples; however, total porosity varied significantly, reaching a max-imum of 15% at 70°C and decreasing to 4–10% at lower temperatures. N-CEC exhibited pH-dependent swelling, with minimal expansion (100–150%) at low pH and a 2–3-fold increase at pH>7, which was at-tributed to COO⁻group formation. These findings position N-CEC as a promising material for pH-responsive applications.

AB - The applicabilityof native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, car-boxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer proper-ties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50°C, 1.07–1.12 at 60°C and 1.16–1.32 at 70°C.Porosity measurements indicated pore sizes ranging from 50 to 200 μm in all samples; however, total porosity varied significantly, reaching a max-imum of 15% at 70°C and decreasing to 4–10% at lower temperatures. N-CEC exhibited pH-dependent swelling, with minimal expansion (100–150%) at low pH and a 2–3-fold increase at pH>7, which was at-tributed to COO⁻group formation. These findings position N-CEC as a promising material for pH-responsive applications.

U2 - 10.31489/2959-0663/2-25-6

DO - 10.31489/2959-0663/2-25-6

M3 - Article

JO - Eurasian Journal of Chemistry

JF - Eurasian Journal of Chemistry

SN - 2959-0663

ER -

ID: 67470870