Research output: Contribution to journal › Article › peer-review
Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA. / Kanygin, Vladimir; Zaboronok, Alexander; Kichigin, Aleksandr et al.
In: Veterinary Sciences, Vol. 10, No. 4, 274, 04.04.2023.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA
AU - Kanygin, Vladimir
AU - Zaboronok, Alexander
AU - Kichigin, Aleksandr
AU - Petrova, Elena
AU - Guselnikova, Tatyana
AU - Kozlov, Andrey
AU - Lukichev, Dmitriy
AU - Mathis, Bryan J
AU - Taskaev, Sergey
N1 - This research was partly supported by the Russian Science Foundation, grant number 23-25-00364, and the Grant-in-Aid for Scientific Research (C) JSPS KAKENHI number 20K07672 by the Japanese Ministry of Education, Culture, Sports, Science and Technology.
PY - 2023/4/4
Y1 - 2023/4/4
N2 - We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.
AB - We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.
KW - VETERINARY MEDICINE
KW - CANCER
KW - SPONTANEOUS TUMORS
KW - LARGE ANIMAL IRRADIATION
KW - GADOLINIUM NEUTRON CAPTURE THERAPY
KW - GDNCT
KW - DIMEGLUMINE GADOPENTETATE
KW - GD-DTPA
KW - BORON NEUTRON CAPTURE THERAPY
KW - BNCT
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85153725560&origin=inward&txGid=084305eb3d1f76e75d70423df43a0e03
UR - https://elibrary.ru/item.asp?id=50741519
U2 - 10.3390/vetsci10040274
DO - 10.3390/vetsci10040274
M3 - Article
C2 - 37104429
VL - 10
JO - Veterinary Sciences
JF - Veterinary Sciences
SN - 2306-7381
IS - 4
M1 - 274
ER -
ID: 48880896