Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

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Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA. / Kanygin, Vladimir; Zaboronok, Alexander; Kichigin, Aleksandr et al.

In: Veterinary Sciences, Vol. 10, No. 4, 274, 04.04.2023.

Research output: Contribution to journal › Article › peer-review

Author

Kanygin, Vladimir ; Zaboronok, Alexander ; Kichigin, Aleksandr et al. / Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA. In: Veterinary Sciences. 2023 ; Vol. 10, No. 4.

BibTeX

@article{797e6e718d4842148e33388bc55d8d4f,

title = "Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA",

abstract = "We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist{\textregistered}, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.",

keywords = "VETERINARY MEDICINE, CANCER, SPONTANEOUS TUMORS, LARGE ANIMAL IRRADIATION, GADOLINIUM NEUTRON CAPTURE THERAPY, GDNCT, DIMEGLUMINE GADOPENTETATE, GD-DTPA, BORON NEUTRON CAPTURE THERAPY, BNCT",

author = "Vladimir Kanygin and Alexander Zaboronok and Aleksandr Kichigin and Elena Petrova and Tatyana Guselnikova and Andrey Kozlov and Dmitriy Lukichev and Mathis, {Bryan J} and Sergey Taskaev",

note = "This research was partly supported by the Russian Science Foundation, grant number 23-25-00364, and the Grant-in-Aid for Scientific Research (C) JSPS KAKENHI number 20K07672 by the Japanese Ministry of Education, Culture, Sports, Science and Technology.",

year = "2023",

month = apr,

day = "4",

doi = "10.3390/vetsci10040274",

language = "English",

volume = "10",

journal = "Veterinary Sciences",

issn = "2306-7381",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

RIS

TY - JOUR

T1 - Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

AU - Kanygin, Vladimir

AU - Zaboronok, Alexander

AU - Kichigin, Aleksandr

AU - Petrova, Elena

AU - Guselnikova, Tatyana

AU - Kozlov, Andrey

AU - Lukichev, Dmitriy

AU - Mathis, Bryan J

AU - Taskaev, Sergey

N1 - This research was partly supported by the Russian Science Foundation, grant number 23-25-00364, and the Grant-in-Aid for Scientific Research (C) JSPS KAKENHI number 20K07672 by the Japanese Ministry of Education, Culture, Sports, Science and Technology.

PY - 2023/4/4

Y1 - 2023/4/4

N2 - We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.

AB - We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.

KW - VETERINARY MEDICINE

KW - CANCER

KW - SPONTANEOUS TUMORS

KW - LARGE ANIMAL IRRADIATION

KW - GADOLINIUM NEUTRON CAPTURE THERAPY

KW - GDNCT

KW - DIMEGLUMINE GADOPENTETATE

KW - GD-DTPA

KW - BORON NEUTRON CAPTURE THERAPY

KW - BNCT

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85153725560&origin=inward&txGid=084305eb3d1f76e75d70423df43a0e03

UR - https://elibrary.ru/item.asp?id=50741519

U2 - 10.3390/vetsci10040274

DO - 10.3390/vetsci10040274

M3 - Article

C2 - 37104429

VL - 10

JO - Veterinary Sciences

JF - Veterinary Sciences

SN - 2306-7381

IS - 4

M1 - 274

ER -

ID: 48880896