TY - JOUR

T1 - Functional polymorphism rs1024611 in the MCP1 gene is associated with the risk of varicose veins of lower extremities

AU - Shadrina, Alexandra S.

AU - Smetanina, Mariya A.

AU - Sevost'ianova, Kseniya S.

AU - Seliverstov, Evgenii I.

AU - Ilyukhin, Evgeny A.

AU - Voronina, Elena N.

AU - Zolotukhin, Igor A.

AU - Filipenko, Maxim L.

N1 - Publisher Copyright: © 2017 Society for Vascular Surgery

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective Monocyte chemoattractant protein 1 (MCP-1) is a chemokine responsible for monocyte, basophil, and T-lymphocyte attraction. Polymorphism rs1024611 located in the regulatory region of the MCP1 gene has previously been shown to be associated with increased MCP-1 production. In our study, we aimed to examine the association of rs1024611 with the risk of primary varicose veins (PVVs) of lower extremities. Methods The case group comprised 470 patients with PVVs, and the control group included 269 individuals without a history of chronic venous disease. All cases and controls were ethnic Russians. Genotypes were determined by real-time polymerase chain reaction allelic discrimination. Association was studied by logistic regression analysis. Results We revealed the association of genotype G/G with the increased risk of PVVs (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.02-3.44; P = .04). In the subgroup analysis, association was revealed only in patients with C2 Clinical, Etiology, Anatomy, and Pathophysiology class (allele G: OR, 1.62 [95% CI, 1.13-2.33; P = .008]; genotype G/G: OR, 3.22 [95% CI, 1.43-7.27; P = .005]), in patients with age at onset of PVVs before 30 years (allele G: OR, 1.41 [95% CI, 1.08-1.85; P = .01]; genotype G/G: OR, 2.35 [95% CI, 1.22-4.55; P = .01]), and in patients who declared no family history (allele G: OR, 1.46 [95% CI, 1.02-2.09; P = .04]; genotype G/G: OR, 2.50 [95% CI, 1.11-5.63; P = .03]). Conclusions Our results provide evidence for MCP-1 involvement in the development of PVVs and indicate that inflammation could be implicated in the pathogenesis of this condition.

AB - Objective Monocyte chemoattractant protein 1 (MCP-1) is a chemokine responsible for monocyte, basophil, and T-lymphocyte attraction. Polymorphism rs1024611 located in the regulatory region of the MCP1 gene has previously been shown to be associated with increased MCP-1 production. In our study, we aimed to examine the association of rs1024611 with the risk of primary varicose veins (PVVs) of lower extremities. Methods The case group comprised 470 patients with PVVs, and the control group included 269 individuals without a history of chronic venous disease. All cases and controls were ethnic Russians. Genotypes were determined by real-time polymerase chain reaction allelic discrimination. Association was studied by logistic regression analysis. Results We revealed the association of genotype G/G with the increased risk of PVVs (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.02-3.44; P = .04). In the subgroup analysis, association was revealed only in patients with C2 Clinical, Etiology, Anatomy, and Pathophysiology class (allele G: OR, 1.62 [95% CI, 1.13-2.33; P = .008]; genotype G/G: OR, 3.22 [95% CI, 1.43-7.27; P = .005]), in patients with age at onset of PVVs before 30 years (allele G: OR, 1.41 [95% CI, 1.08-1.85; P = .01]; genotype G/G: OR, 2.35 [95% CI, 1.22-4.55; P = .01]), and in patients who declared no family history (allele G: OR, 1.46 [95% CI, 1.02-2.09; P = .04]; genotype G/G: OR, 2.50 [95% CI, 1.11-5.63; P = .03]). Conclusions Our results provide evidence for MCP-1 involvement in the development of PVVs and indicate that inflammation could be implicated in the pathogenesis of this condition.

KW - MONOCYTE CHEMOATTRACTANT PROTEIN-1

KW - REGULATORY REGION

KW - MYOCARDIAL-INFARCTION

KW - DISEASE

KW - EXPRESSION

KW - ALLELE

KW - PATHOGENESIS

KW - METAANALYSIS

KW - CCL2

KW - Predictive Value of Tests

KW - Humans

KW - Middle Aged

KW - Male

KW - Case-Control Studies

KW - Russia

KW - Sensitivity and Specificity

KW - Aged, 80 and over

KW - Adult

KW - Biomarkers/blood

KW - Female

KW - Chemokine CCL2/blood

KW - Genetic Predisposition to Disease

KW - Risk Factors

KW - Hospitals, University

KW - Genotype

KW - Varicose Veins/diagnosis

KW - Adolescent

KW - Alleles

KW - Lower Extremity

KW - Aged

KW - Polymorphism, Single Nucleotide

UR - http://www.scopus.com/inward/record.url?scp=85013073319&partnerID=8YFLogxK

U2 - 10.1016/j.jvsv.2016.12.008

DO - 10.1016/j.jvsv.2016.12.008

M3 - Article

C2 - 28623996

AN - SCOPUS:85013073319

VL - 5

SP - 561

EP - 566

JO - Journal of Vascular Surgery: Venous and Lymphatic Disorders

JF - Journal of Vascular Surgery: Venous and Lymphatic Disorders

SN - 2213-333X

IS - 4

ER -