TY - JOUR

T1 - Functional Connectivity of Brain Regions According to Resting State fMRI

T2 - Differences between Healthy and Depressed Subjects and Variability of the Results

AU - Bezmaternykh, D. D.

AU - Mel’nikov, M. E.

AU - Kozlova, L. I.

AU - Shtark, M. B.

AU - Savelov, A. A.

AU - Petrovskii, E. D.

AU - Shubina, O. S.

AU - Natarova, K. A.

N1 - Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - In depressed patients, changes in spontaneous brain activity, in particular, the strength of functional connectivity between different regions are observed. The data on changes in the synchrony of different regions of interest in the brain can serve as markers of depressive symptoms and as the targets for the corresponding therapy. The study involved 21 patients with mild depression and 21 healthy volunteers; by the time of second fMRI scanning, 15 and 19 subjects, respectively). The subjects underwent two 4-min sessions of resting state fMRI with 2-4 months interval between the recordings; on the basis of these data, functional connectivity between regions of interest was assessed. During the first session, depressed patients demonstrated more pronounced connection between the right frontal eye field and cerebellar area III. When the sample was restricted to subjects who underwent both fMRI sessions, depressed patients demonstrated closer relations of the right parietal operculum and cerebellar vermis area VIII. During the second recording, healthy subjects showed stronger connectivity between more than 20 frontal, temporal, and subcortical regions of interest and cerebellum area II. In healthy participants, brainstem functional interactions increased from the first to the second fMRI-recording. In depressed subjects a number of cortical areas split from left intraparietal sulcus, but the left temporal cortex became more intra-connected. The results confirm the differences in functional connectivity between depressed and healthy subjects. At the same time, attention should be paid to the variability of the data obtained.

AB - In depressed patients, changes in spontaneous brain activity, in particular, the strength of functional connectivity between different regions are observed. The data on changes in the synchrony of different regions of interest in the brain can serve as markers of depressive symptoms and as the targets for the corresponding therapy. The study involved 21 patients with mild depression and 21 healthy volunteers; by the time of second fMRI scanning, 15 and 19 subjects, respectively). The subjects underwent two 4-min sessions of resting state fMRI with 2-4 months interval between the recordings; on the basis of these data, functional connectivity between regions of interest was assessed. During the first session, depressed patients demonstrated more pronounced connection between the right frontal eye field and cerebellar area III. When the sample was restricted to subjects who underwent both fMRI sessions, depressed patients demonstrated closer relations of the right parietal operculum and cerebellar vermis area VIII. During the second recording, healthy subjects showed stronger connectivity between more than 20 frontal, temporal, and subcortical regions of interest and cerebellum area II. In healthy participants, brainstem functional interactions increased from the first to the second fMRI-recording. In depressed subjects a number of cortical areas split from left intraparietal sulcus, but the left temporal cortex became more intra-connected. The results confirm the differences in functional connectivity between depressed and healthy subjects. At the same time, attention should be paid to the variability of the data obtained.

KW - connectivity between regions of interest

KW - depression

KW - functional connectivity

KW - reliability of fMRI data

KW - resting state fMRI

UR - http://www.scopus.com/inward/record.url?scp=85055454972&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4254-z

DO - 10.1007/s10517-018-4254-z

M3 - Article

C2 - 30353343

AN - SCOPUS:85055454972

VL - 165

SP - 734

EP - 740

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 6

ER -