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Function and Evolution of the Loop Extrusion Machinery in Animals. / Kabirova, Evelyn; Nurislamov, Artem; Shadskiy, Artem et al.

In: International Journal of Molecular Sciences, Vol. 24, No. 5, 5017, 06.03.2023.

Research output: Contribution to journal › Review article › peer-review

Harvard

Kabirova, E, Nurislamov, A, Shadskiy, A, Smirnov, A, Popov, A, Salnikov, P, Battulin, N & Fishman, V 2023, 'Function and Evolution of the Loop Extrusion Machinery in Animals', International Journal of Molecular Sciences, vol. 24, no. 5, 5017. https://doi.org/10.3390/ijms24055017

APA

Kabirova, E., Nurislamov, A., Shadskiy, A., Smirnov, A., Popov, A., Salnikov, P., Battulin, N., & Fishman, V. (2023). Function and Evolution of the Loop Extrusion Machinery in Animals. International Journal of Molecular Sciences, 24(5), [5017]. https://doi.org/10.3390/ijms24055017

Vancouver

Kabirova E, Nurislamov A, Shadskiy A, Smirnov A, Popov A, Salnikov P et al. Function and Evolution of the Loop Extrusion Machinery in Animals. International Journal of Molecular Sciences. 2023 Mar 6;24(5):5017. doi: 10.3390/ijms24055017

Author

Kabirova, Evelyn ; Nurislamov, Artem ; Shadskiy, Artem et al. / Function and Evolution of the Loop Extrusion Machinery in Animals. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 5.

BibTeX

@article{7ef657adcfa94177905a3047d3232df0,
title = "Function and Evolution of the Loop Extrusion Machinery in Animals",
abstract = "Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago. Recent advances in chromatin biology showed that SMC proteins are involved in many other genomic processes, acting as active motors extruding DNA, which leads to the formation of chromatin loops. Some loops formed by SMC proteins are highly cell type and developmental stage specific, such as SMC-mediated DNA loops required for VDJ recombination in B-cell progenitors, or dosage compensation in Caenorhabditis elegans and X-chromosome inactivation in mice. In this review, we focus on the extrusion-based mechanisms that are common for multiple cell types and species. We will first describe an anatomy of SMC complexes and their accessory proteins. Next, we provide biochemical details of the extrusion process. We follow this by the sections describing the role of SMC complexes in gene regulation, DNA repair, and chromatin topology.",
keywords = "SMC complexes, cohesion, evolution, gene regulation, loop extrusion",
author = "Evelyn Kabirova and Artem Nurislamov and Artem Shadskiy and Alexander Smirnov and Andrey Popov and Pavel Salnikov and Nariman Battulin and Veniamin Fishman",
note = "Funding: Preparation of the review was supported by Russian Science Foundation grant #22-14-00247.",
year = "2023",
month = mar,
day = "6",
doi = "10.3390/ijms24055017",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",

}

RIS

TY - JOUR

T1 - Function and Evolution of the Loop Extrusion Machinery in Animals

AU - Kabirova, Evelyn

AU - Nurislamov, Artem

AU - Shadskiy, Artem

AU - Smirnov, Alexander

AU - Popov, Andrey

AU - Salnikov, Pavel

AU - Battulin, Nariman

AU - Fishman, Veniamin

N1 - Funding: Preparation of the review was supported by Russian Science Foundation grant #22-14-00247.

PY - 2023/3/6

Y1 - 2023/3/6

N2 - Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago. Recent advances in chromatin biology showed that SMC proteins are involved in many other genomic processes, acting as active motors extruding DNA, which leads to the formation of chromatin loops. Some loops formed by SMC proteins are highly cell type and developmental stage specific, such as SMC-mediated DNA loops required for VDJ recombination in B-cell progenitors, or dosage compensation in Caenorhabditis elegans and X-chromosome inactivation in mice. In this review, we focus on the extrusion-based mechanisms that are common for multiple cell types and species. We will first describe an anatomy of SMC complexes and their accessory proteins. Next, we provide biochemical details of the extrusion process. We follow this by the sections describing the role of SMC complexes in gene regulation, DNA repair, and chromatin topology.

AB - Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago. Recent advances in chromatin biology showed that SMC proteins are involved in many other genomic processes, acting as active motors extruding DNA, which leads to the formation of chromatin loops. Some loops formed by SMC proteins are highly cell type and developmental stage specific, such as SMC-mediated DNA loops required for VDJ recombination in B-cell progenitors, or dosage compensation in Caenorhabditis elegans and X-chromosome inactivation in mice. In this review, we focus on the extrusion-based mechanisms that are common for multiple cell types and species. We will first describe an anatomy of SMC complexes and their accessory proteins. Next, we provide biochemical details of the extrusion process. We follow this by the sections describing the role of SMC complexes in gene regulation, DNA repair, and chromatin topology.

KW - SMC complexes

KW - cohesion

KW - evolution

KW - gene regulation

KW - loop extrusion

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85149896945&origin=inward&txGid=afa3865133a717f85b87d4a7a7f586bb

UR - https://www.mendeley.com/catalogue/2eb7f64b-e249-3400-bfa8-b45e17201003/

U2 - 10.3390/ijms24055017

DO - 10.3390/ijms24055017

M3 - Review article

C2 - 36902449

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 5

M1 - 5017

ER -

ID: 45280086