Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals

Original language	English
Pages (from-to)	36-49
Number of pages	14
Journal	Journal of Pharmaceutical Sciences
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/j.xphs.2018.07.018
Publication status	Published - 1 Jan 2019

amorphism, chemical stability, deamidation, freeze-drying, lyophilization, protein formulation(s), solid-state, stability, structure, water sorption, GLASS TRANSITIONS, LYOPHILIZED SOLIDS, LIQUID TRANSITION, PROTEIN-STRUCTURE, MOLECULAR MOBILITY, X-RAY-DIFFRACTION, HYDROGEN/DEUTERIUM EXCHANGE, MONOCLONAL-ANTIBODY, GLUCOSE SOLUTIONS, HYDROGEN-DEUTERIUM EXCHANGE, Temperature, Freezing, Chemical Phenomena, Solutions/chemistry, Freeze Drying/methods, Drug Stability, Water/chemistry, Hydrolysis, Chemistry, Pharmaceutical/methods

ID: 16956877

Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals: Water Clusters Hypothesis