Freeze-thaw of pharmaceutical solutions: counter-intuitive finding of an increase in mechanical stress between Tg” and Tg’ in frozen sucrose/water mixtures

Original language	English
Article number	103800
Pages (from-to)	103800
Journal	Journal of Pharmaceutical Sciences
Volume	114
Issue number	7
Early online date	23 Apr 2025
DOIs	https://doi.org/10.1016/j.xphs.2025.103800
Publication status	E-pub ahead of print - 23 Apr 2025

Aqueous solutions, Freezing, Ice crystals, Microstrain, Size of crystalline domains, Synchrotron X-ray diffraction

ID: 66565039