Standard

Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe. / Mitin, Dmitry E; Chubarov, Alexey S.

In: Molecules (Basel, Switzerland), Vol. 28, No. 4, 1695, 10.02.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Mitin, DE & Chubarov, AS 2023, 'Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe', Molecules (Basel, Switzerland), vol. 28, no. 4, 1695. https://doi.org/10.3390/molecules28041695

APA

Mitin, D. E., & Chubarov, A. S. (2023). Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe. Molecules (Basel, Switzerland), 28(4), [1695]. https://doi.org/10.3390/molecules28041695

Vancouver

Mitin DE, Chubarov AS. Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe. Molecules (Basel, Switzerland). 2023 Feb 10;28(4):1695. doi: 10.3390/molecules28041695

Author

Mitin, Dmitry E ; Chubarov, Alexey S. / Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe. In: Molecules (Basel, Switzerland). 2023 ; Vol. 28, No. 4.

BibTeX

@article{2e189febccfc4162b9245193e2359cb5,
title = "Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe",
abstract = "Fluorinated human serum albumin conjugates were prepared and tested as potential metal-free probes for 19F magnetic resonance imaging (MRI). Each protein molecule was modified by several fluorine-containing compounds via the N-substituted natural acylating reagent homocysteine thiolactone. Albumin conjugates retain the protein's physical and biological properties, such as its 3D dimensional structure, aggregation ability, good solubility, proteolysis efficiency, biocompatibility, and low cytotoxicity. A dual-labeled with cyanine 7 fluorescence dye and fluorine reporter group albumin were synthesized for simultaneous fluorescence imaging and 19F MRI. The preliminary in vitro studies show the prospects of albumin carriers for multimodal imaging.",
keywords = "19F-NMR, N-homocysteinylation, fluorinated homocysteine thiolactone, human serum albumin, magnetic resonance imaging probes, octafluorotoluene, perfluoro-m-xylene",
author = "Mitin, {Dmitry E} and Chubarov, {Alexey S}",
note = "Funding: This research was funded by the Russian Science Foundation (grant no. 21-74-00120) and the protein proteolysis studies was supported by the Russian state-funded project for ICBFM SB RAS (grant number 121112900217-3).",
year = "2023",
month = feb,
day = "10",
doi = "10.3390/molecules28041695",
language = "English",
volume = "28",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe

AU - Mitin, Dmitry E

AU - Chubarov, Alexey S

N1 - Funding: This research was funded by the Russian Science Foundation (grant no. 21-74-00120) and the protein proteolysis studies was supported by the Russian state-funded project for ICBFM SB RAS (grant number 121112900217-3).

PY - 2023/2/10

Y1 - 2023/2/10

N2 - Fluorinated human serum albumin conjugates were prepared and tested as potential metal-free probes for 19F magnetic resonance imaging (MRI). Each protein molecule was modified by several fluorine-containing compounds via the N-substituted natural acylating reagent homocysteine thiolactone. Albumin conjugates retain the protein's physical and biological properties, such as its 3D dimensional structure, aggregation ability, good solubility, proteolysis efficiency, biocompatibility, and low cytotoxicity. A dual-labeled with cyanine 7 fluorescence dye and fluorine reporter group albumin were synthesized for simultaneous fluorescence imaging and 19F MRI. The preliminary in vitro studies show the prospects of albumin carriers for multimodal imaging.

AB - Fluorinated human serum albumin conjugates were prepared and tested as potential metal-free probes for 19F magnetic resonance imaging (MRI). Each protein molecule was modified by several fluorine-containing compounds via the N-substituted natural acylating reagent homocysteine thiolactone. Albumin conjugates retain the protein's physical and biological properties, such as its 3D dimensional structure, aggregation ability, good solubility, proteolysis efficiency, biocompatibility, and low cytotoxicity. A dual-labeled with cyanine 7 fluorescence dye and fluorine reporter group albumin were synthesized for simultaneous fluorescence imaging and 19F MRI. The preliminary in vitro studies show the prospects of albumin carriers for multimodal imaging.

KW - 19F-NMR

KW - N-homocysteinylation

KW - fluorinated homocysteine thiolactone

KW - human serum albumin

KW - magnetic resonance imaging probes

KW - octafluorotoluene

KW - perfluoro-m-xylene

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85149054356&origin=inward&txGid=0ca864e052b415c6306750c41a8c7fd9

UR - https://www.mendeley.com/catalogue/e6156b1b-64c2-3852-bbdd-477183092222/

U2 - 10.3390/molecules28041695

DO - 10.3390/molecules28041695

M3 - Article

C2 - 36838682

VL - 28

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 4

M1 - 1695

ER -

ID: 44521918