Research output: Contribution to journal › Article › peer-review
First Report of the Yezo Virus Isolates Detection in Russia. / Kartashov, Mikhail; Svirin, Kirill; Zheleznova, Alina et al.
In: Viruses, Vol. 17, No. 8, 1125, 15.08.2025.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - First Report of the Yezo Virus Isolates Detection in Russia
AU - Kartashov, Mikhail
AU - Svirin, Kirill
AU - Zheleznova, Alina
AU - Yanshin, Alexey
AU - Radchenko, Nikita
AU - Kurushina, Valentina
AU - Tregubchak, Tatyana
AU - Maksimenko, Lada
AU - Sivay, Mariya
AU - Ternovoi, Vladimir
AU - Agafonov, Alexander
AU - Gladysheva, Anastasia
N1 - The work was supported by the Ministry of Science and Higher Education of the Russian Federation (The Federal Scientific-technical program for genetic technologies development for 2019–2030, Agreement No. 075-15-2025-526).
PY - 2025/8/15
Y1 - 2025/8/15
N2 - The recent discovery of the Yezo virus (YEZV) in Japan and China has raised particular concern due to its potential to cause human diseases ranging from mild febrile illnesses to severe neurological disorders. We report, for the first time, the detection of five YEZV isolates in I. persulcatus ticks from three regions of Russia. The analysis was performed using 5318 ticks of two Ixodes genus collected in 2024 from 23 regions of Russia. The minimum infection rate of YEZV in Russia among I. persulcatus ticks was 0.12% (95% CI: 0.05–0.28). The westernmost and northernmost YEZV detection points have been recorded. YEZV isolates circulating in Russia are genetically diverse. Protein domains of Russian YEZV isolates’ genomes were characterized using HMMER, AlphaFold 3, and InterProScan. The YEZV nucleoprotein (N) of Russian isolates has a racket-shaped structure with “head” and “stalk” domains similar to those of Orthonairovirus haemorrhagiae. The Lys261–Arg261 substitution in the YEZV N Chita 2024-1 isolate occurs in the α11 structure in the region of interaction with viral RNA. Our results show that the distribution area of YEZV is much wider than previously known, provide new data on complete YEZV genomes, extend our structural insight into YEZV N, and suggest a potential target for antiviral drug development to treat YEZV infection.
AB - The recent discovery of the Yezo virus (YEZV) in Japan and China has raised particular concern due to its potential to cause human diseases ranging from mild febrile illnesses to severe neurological disorders. We report, for the first time, the detection of five YEZV isolates in I. persulcatus ticks from three regions of Russia. The analysis was performed using 5318 ticks of two Ixodes genus collected in 2024 from 23 regions of Russia. The minimum infection rate of YEZV in Russia among I. persulcatus ticks was 0.12% (95% CI: 0.05–0.28). The westernmost and northernmost YEZV detection points have been recorded. YEZV isolates circulating in Russia are genetically diverse. Protein domains of Russian YEZV isolates’ genomes were characterized using HMMER, AlphaFold 3, and InterProScan. The YEZV nucleoprotein (N) of Russian isolates has a racket-shaped structure with “head” and “stalk” domains similar to those of Orthonairovirus haemorrhagiae. The Lys261–Arg261 substitution in the YEZV N Chita 2024-1 isolate occurs in the α11 structure in the region of interaction with viral RNA. Our results show that the distribution area of YEZV is much wider than previously known, provide new data on complete YEZV genomes, extend our structural insight into YEZV N, and suggest a potential target for antiviral drug development to treat YEZV infection.
KW - AlphaFold
KW - Ixodes persulcatus
KW - Orthonairovirus
KW - Yezo virus
KW - nucleoprotein
KW - protein structure
KW - tick-borne diseases
KW - ticks
UR - https://www.scopus.com/pages/publications/105014269646
UR - https://www.mendeley.com/catalogue/0c221f32-a9a0-37a9-8834-81a9c40acbe6/
U2 - 10.3390/v17081125
DO - 10.3390/v17081125
M3 - Article
C2 - 40872839
VL - 17
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 8
M1 - 1125
ER -
ID: 68948117