TY - JOUR

T1 - Expression density of receptors for immunoregulatory mediators as a modulatory component of biological effects of mediators upon cells (Part 1)

AU - Sennikov, S. V.

AU - Alshevskaya, A. A.

AU - Zhukova, Yu V.

AU - Belomestnova, I. A.

AU - Karaulov, A. V.

AU - Lopatnikova, Yu A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.

AB - The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.

KW - Cytokines

KW - Growth factors

KW - Immunopathology

KW - Immunoregulation

KW - Immunotherapy

KW - Interferons

KW - Interleukins

KW - Receptors

KW - Tumor necrosis facto

UR - http://www.scopus.com/inward/record.url?scp=85067959748&partnerID=8YFLogxK

U2 - 10.15789/1563-0625-2019-2-209-220

DO - 10.15789/1563-0625-2019-2-209-220

M3 - Review article

AN - SCOPUS:85067959748

VL - 21

SP - 209

EP - 220

JO - Medical Immunology (Russia)

JF - Medical Immunology (Russia)

SN - 1563-0625

IS - 2

ER -