Standard

Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors. / Nikolin, V. P.; Bogachev, S. S.; Popova, N. A. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 5, 01.09.2017, p. 639-642.

Research output: Contribution to journal › Article › peer-review

Harvard

Nikolin, VP, Bogachev, SS, Popova, NA, Tornuev, YV & Vinogradova, EV 2017, 'Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors', Bulletin of Experimental Biology and Medicine, vol. 163, no. 5, pp. 639-642. https://doi.org/10.1007/s10517-017-3868-x

APA

Nikolin, V. P., Bogachev, S. S., Popova, N. A., Tornuev, Y. V., & Vinogradova, E. V. (2017). Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors. Bulletin of Experimental Biology and Medicine, 163(5), 639-642. https://doi.org/10.1007/s10517-017-3868-x

Vancouver

Nikolin VP, Bogachev SS, Popova NA, Tornuev YV, Vinogradova EV. Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors. Bulletin of Experimental Biology and Medicine. 2017 Sept 1;163(5):639-642. doi: 10.1007/s10517-017-3868-x

Author

Nikolin, V. P. ; Bogachev, S. S. ; Popova, N. A. et al. / Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 5. pp. 639-642.

BibTeX

@article{36cfd17a2ee9424c988d143b4ea2251a,
title = "Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors",
abstract = "We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.",
keywords = "experimental tumor metastases in the lungs, leukemia L-1210, radioprotectors, radiotherapy, yeast RNA preparation, EXPOSURE",
author = "Nikolin, {V. P.} and Bogachev, {S. S.} and Popova, {N. A.} and Tornuev, {Yu V.} and Vinogradova, {E. V.}",
year = "2017",
month = sep,
day = "1",
doi = "10.1007/s10517-017-3868-x",
language = "English",
volume = "163",
pages = "639--642",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "5",

}

RIS

TY - JOUR

T1 - Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors

AU - Nikolin, V. P.

AU - Bogachev, S. S.

AU - Popova, N. A.

AU - Tornuev, Yu V.

AU - Vinogradova, E. V.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.

AB - We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.

KW - experimental tumor metastases in the lungs

KW - leukemia L-1210

KW - radioprotectors

KW - radiotherapy

KW - yeast RNA preparation

KW - EXPOSURE

UR - http://www.scopus.com/inward/record.url?scp=85029803670&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3868-x

DO - 10.1007/s10517-017-3868-x

M3 - Article

C2 - 28948545

AN - SCOPUS:85029803670

VL - 163

SP - 639

EP - 642

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -

ID: 9909406