Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins

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Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins. / Popova, N. A.; Nikolin, V. P.; Kaledin, V. I. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 173, No. 1, 05.2022, p. 105-109.

Research output: Contribution to journal › Article › peer-review

Harvard

Popova, NA, Nikolin, VP, Kaledin, VI, Serova, IA, Matyunina, EA, Bakarev, MA, Lushnikova, EL & Vologodskii, AN 2022, 'Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins', Bulletin of Experimental Biology and Medicine, vol. 173, no. 1, pp. 105-109. https://doi.org/10.1007/s10517-022-05502-6

APA

Popova, N. A., Nikolin, V. P., Kaledin, V. I., Serova, I. A., Matyunina, E. A., Bakarev, M. A., Lushnikova, E. L., & Vologodskii, A. N. (2022). Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins. Bulletin of Experimental Biology and Medicine, 173(1), 105-109. https://doi.org/10.1007/s10517-022-05502-6

Vancouver

Popova NA, Nikolin VP, Kaledin VI, Serova IA, Matyunina EA, Bakarev MA et al. Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins. Bulletin of Experimental Biology and Medicine. 2022 May;173(1):105-109. doi: 10.1007/s10517-022-05502-6

Author

Popova, N. A. ; Nikolin, V. P. ; Kaledin, V. I. et al. / Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins. In: Bulletin of Experimental Biology and Medicine. 2022 ; Vol. 173, No. 1. pp. 105-109.

BibTeX

@article{b0051eabcedb4300bd64c55b8f99a6ab,

title = "Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins",

abstract = "We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium salts) is covalently linked to peptides containing the RGD motif. The antitumor and pronounced antimetastatic effects of Pefagtal were demonstrated on transplanted mouse tumors differing in histological type and status of metastasis: Krebs-2 ascites adenocarcinoma of the mammary gland, Lewis lung adenocarcinoma, hepatoma-29, and lung adenocarcinoma. It is assumed that the RGD motif mediates primary binding of the construct to αvβ3 and αvβ5 integrins that are predominantly overexpressed in the endothelial cells of tumor blood vessels and in tumor and metastatic cells.",

keywords = "drug Pefagtal, metastases, mice tumors, targeted therapy, αvβ3 integrins, Adenocarcinoma of Lung, Integrin alphaVbeta3/metabolism, Oligopeptides/chemistry, Liver Neoplasms, Animals, Endothelial Cells/metabolism, Mice, Carcinoma, Hepatocellular",

author = "Popova, {N. A.} and Nikolin, {V. P.} and Kaledin, {V. I.} and Serova, {I. A.} and Matyunina, {E. A.} and Bakarev, {M. A.} and Lushnikova, {E. L.} and Vologodskii, {A. N.}",

note = "Publisher Copyright: {\textcopyright} 2022, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = may,

doi = "10.1007/s10517-022-05502-6",

language = "English",

volume = "173",

pages = "105--109",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer New York",

number = "1",

}

RIS

TY - JOUR

T1 - Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins

AU - Popova, N. A.

AU - Nikolin, V. P.

AU - Kaledin, V. I.

AU - Serova, I. A.

AU - Matyunina, E. A.

AU - Bakarev, M. A.

AU - Lushnikova, E. L.

AU - Vologodskii, A. N.

PY - 2022/5

Y1 - 2022/5

N2 - We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium salts) is covalently linked to peptides containing the RGD motif. The antitumor and pronounced antimetastatic effects of Pefagtal were demonstrated on transplanted mouse tumors differing in histological type and status of metastasis: Krebs-2 ascites adenocarcinoma of the mammary gland, Lewis lung adenocarcinoma, hepatoma-29, and lung adenocarcinoma. It is assumed that the RGD motif mediates primary binding of the construct to αvβ3 and αvβ5 integrins that are predominantly overexpressed in the endothelial cells of tumor blood vessels and in tumor and metastatic cells.

AB - We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium salts) is covalently linked to peptides containing the RGD motif. The antitumor and pronounced antimetastatic effects of Pefagtal were demonstrated on transplanted mouse tumors differing in histological type and status of metastasis: Krebs-2 ascites adenocarcinoma of the mammary gland, Lewis lung adenocarcinoma, hepatoma-29, and lung adenocarcinoma. It is assumed that the RGD motif mediates primary binding of the construct to αvβ3 and αvβ5 integrins that are predominantly overexpressed in the endothelial cells of tumor blood vessels and in tumor and metastatic cells.

KW - drug Pefagtal

KW - metastases

KW - mice tumors

KW - targeted therapy

KW - αvβ3 integrins

KW - Adenocarcinoma of Lung

KW - Integrin alphaVbeta3/metabolism

KW - Oligopeptides/chemistry

KW - Liver Neoplasms

KW - Animals

KW - Endothelial Cells/metabolism

KW - Mice

KW - Carcinoma, Hepatocellular

UR - http://www.scopus.com/inward/record.url?scp=85130714709&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/972589b8-f770-30b9-9643-3b2625cb7d89/

U2 - 10.1007/s10517-022-05502-6

DO - 10.1007/s10517-022-05502-6

M3 - Article

C2 - 35618966

AN - SCOPUS:85130714709

VL - 173

SP - 105

EP - 109

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 36188695