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Epigenetic Mechanisms of Blood-Pressure Regulation. / Markel, A. L.; Redina, O. E.

In: Molecular Biology, Vol. 52, No. 2, 01.03.2018, p. 151-164.

Research output: Contribution to journal › Review article › peer-review

Harvard

Markel, AL & Redina, OE 2018, 'Epigenetic Mechanisms of Blood-Pressure Regulation', Molecular Biology, vol. 52, no. 2, pp. 151-164. https://doi.org/10.1134/S0026893317050120

APA

Markel, A. L., & Redina, O. E. (2018). Epigenetic Mechanisms of Blood-Pressure Regulation. Molecular Biology, 52(2), 151-164. https://doi.org/10.1134/S0026893317050120

Vancouver

Markel AL, Redina OE. Epigenetic Mechanisms of Blood-Pressure Regulation. Molecular Biology. 2018 Mar 1;52(2):151-164. doi: 10.1134/S0026893317050120

Author

Markel, A. L. ; Redina, O. E. / Epigenetic Mechanisms of Blood-Pressure Regulation. In: Molecular Biology. 2018 ; Vol. 52, No. 2. pp. 151-164.

BibTeX

@article{b73b0aa1b78e4560b9632e3a2ed156f5,
title = "Epigenetic Mechanisms of Blood-Pressure Regulation",
abstract = "The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.",
keywords = "blood pressure, epigenetic mechanisms, hypertension",
author = "Markel, {A. L.} and Redina, {O. E.}",
year = "2018",
month = mar,
day = "1",
doi = "10.1134/S0026893317050120",
language = "English",
volume = "52",
pages = "151--164",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Epigenetic Mechanisms of Blood-Pressure Regulation

AU - Markel, A. L.

AU - Redina, O. E.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

AB - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

KW - blood pressure

KW - epigenetic mechanisms

KW - hypertension

UR - http://www.scopus.com/inward/record.url?scp=85045532887&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=32619491

U2 - 10.1134/S0026893317050120

DO - 10.1134/S0026893317050120

M3 - Review article

AN - SCOPUS:85045532887

VL - 52

SP - 151

EP - 164

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 2

ER -

ID: 12668550