Research output: Contribution to journal › Review article › peer-review
ENIGMA MDD : seven years of global neuroimaging studies of major depression through worldwide data sharing. / The ENIGMA-MDD DTI Working Group.
In: Translational Psychiatry, Vol. 10, No. 1, 172, 29.05.2020.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - ENIGMA MDD
T2 - seven years of global neuroimaging studies of major depression through worldwide data sharing
AU - The ENIGMA-MDD DTI Working Group
AU - Schmaal, Lianne
AU - Pozzi, Elena
AU - C. Ho, Tiffany
AU - van Velzen, Laura S.
AU - Veer, Ilya M.
AU - Opel, Nils
AU - Van Someren, Eus J.W.
AU - Han, Laura K.M.
AU - Aftanas, Lybomir
AU - Aleman, André
AU - Baune, Bernhard T.
AU - Berger, Klaus
AU - Blanken, Tessa F.
AU - Capitão, Liliana
AU - Couvy-Duchesne, Baptiste
AU - R. Cullen, Kathryn
AU - Dannlowski, Udo
AU - Davey, Christopher
AU - Erwin-Grabner, Tracy
AU - Evans, Jennifer
AU - Frodl, Thomas
AU - Fu, Cynthia H.Y.
AU - Godlewska, Beata
AU - Gotlib, Ian H.
AU - Goya-Maldonado, Roberto
AU - Grabe, Hans J.
AU - Groenewold, Nynke A.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Gutman, Boris A.
AU - Hall, Geoffrey B.
AU - Harrison, Ben J.
AU - Hatton, Sean N.
AU - Hermesdorf, Marco
AU - Hickie, Ian B.
AU - Hilland, Eva
AU - Irungu, Benson
AU - Jonassen, Rune
AU - Kelly, Sinead
AU - Kircher, Tilo
AU - Klimes-Dougan, Bonnie
AU - Krug, Axel
AU - Landrø, Nils Inge
AU - Lagopoulos, Jim
AU - Leerssen, Jeanne
AU - Li, Meng
AU - Linden, David E.J.
AU - MacMaster, Frank P.
AU - M. McIntosh, Andrew
AU - Mehler, David M.A.
N1 - Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/29
Y1 - 2020/5/29
N2 - A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
AB - A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
KW - POSTTRAUMATIC-STRESS-DISORDER
KW - ANTERIOR CORONA RADIATA
KW - WHITE-MATTER INTEGRITY
KW - CORTICAL SURFACE-AREA
KW - STAR-ASTERISK-D
KW - CHILDHOOD MALTREATMENT
KW - HIPPOCAMPAL VOLUME
KW - PSYCHIATRIC-DISORDERS
KW - LONGITUDINAL CHANGES
KW - GENETIC INFLUENCES
UR - http://www.scopus.com/inward/record.url?scp=85085688346&partnerID=8YFLogxK
U2 - 10.1038/s41398-020-0842-6
DO - 10.1038/s41398-020-0842-6
M3 - Review article
C2 - 32472038
AN - SCOPUS:85085688346
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
SN - 2158-3188
IS - 1
M1 - 172
ER -
ID: 24412029