Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	108-118
Number of pages	11
Journal	International Journal of Pharmaceutics
Volume	534
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.10.011
Publication status	Published - 20 Dec 2017

Mechanochemistry, Pharmacokinetics, Simvastatin, Solubility, Supramolecular complexes, DRUG-DELIVERY-SYSTEM, PERMEABILITY, SOLUBLE INTERMOLECULAR COMPLEXES, GLYCYRRHIZIC ACID, SOLID DISPERSIONS, BETA-CYCLODEXTRIN, ARTIFICIAL MEMBRANE, DISSOLUTION RATE, POLYSACCHARIDE ARABINOGALACTAN, INCLUSION COMPLEX, Glycyrrhizic Acid/chemistry, Biological Availability, Male, Drug Carriers/chemistry, Micelles, Galactans/chemistry, Administration, Oral, Solvents/chemistry, Simvastatin/chemistry, Polysaccharides/chemistry, Permeability/drug effects, Animals, Solubility/drug effects, Mice

ID: 9429088