Research output: Contribution to journal › Article › peer-review
Endometrial vascularisation in hyperplasia without atypia. / Maiborodin, I. V.; Goncharov, M. A.; Sheplev, B. V. et al.
In: Arkhiv Patologii, Vol. 87, No. 6, 4, 2025, p. 28-33.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Endometrial vascularisation in hyperplasia without atypia
AU - Maiborodin, I. V.
AU - Goncharov, M. A.
AU - Sheplev, B. V.
AU - Shumeikina, A. O.
AU - Krasil’nikov, S. E.
AU - Chernomortseva, E. S.
N1 - Maiborodin IV, Goncharov MA, Sheplev BV, Shumeikina AO, Krasil’nikov SE, Chernomortseva ES. Endometrial vascularisation in hyperplasia without atypia. Russian Journal of Archive of Pathology. 2025;87(6):28‑33. (In Russ.) https://doi.org/10.17116/patol20258706128
PY - 2025
Y1 - 2025
N2 - Various benign processes in the endometrium are the cause of vascular changes. Endometrial cancer is also accompanied by changes in the density of microvessels. The detection of vascularization of the hyperplastic endometrium without signs of atypia, expressed significantly more than described in the literature, served as the basis for this work. Objective. To assess the state of the vascularization of the simple endometrial hyperplasia without atypia and to compare the obtained results with literary data. Material and methods. Vascularization of the endometrium in its simple hyperplasia without atypia was studied in 31 women by light microscopy using an immunohistochemical reaction with antibodies to the CD34 antigen and morphometry. Results. Different patients had different degrees of expression, but always large, vascularization of the endometrium with simple endometrial hyperplasia without atypia. The vessels accounted 5.97±4.18% of the section area, while their number per 1 mm2 was 391±180. These data significantly exceed most of the results of other studies presented in the literature, which differ several times even from each other. Conclusion. Endometrium with simple endometrial hyperplasia without atypia is characterized by different, often very high levels of vascularization, the real average values much exceed most of the literary data, which are also very contradictory. A very critical attention to the results describing the features of angiogenesis and vascularization of hyperplastic endometrium without atypia is necessary.
AB - Various benign processes in the endometrium are the cause of vascular changes. Endometrial cancer is also accompanied by changes in the density of microvessels. The detection of vascularization of the hyperplastic endometrium without signs of atypia, expressed significantly more than described in the literature, served as the basis for this work. Objective. To assess the state of the vascularization of the simple endometrial hyperplasia without atypia and to compare the obtained results with literary data. Material and methods. Vascularization of the endometrium in its simple hyperplasia without atypia was studied in 31 women by light microscopy using an immunohistochemical reaction with antibodies to the CD34 antigen and morphometry. Results. Different patients had different degrees of expression, but always large, vascularization of the endometrium with simple endometrial hyperplasia without atypia. The vessels accounted 5.97±4.18% of the section area, while their number per 1 mm2 was 391±180. These data significantly exceed most of the results of other studies presented in the literature, which differ several times even from each other. Conclusion. Endometrium with simple endometrial hyperplasia without atypia is characterized by different, often very high levels of vascularization, the real average values much exceed most of the literary data, which are also very contradictory. A very critical attention to the results describing the features of angiogenesis and vascularization of hyperplastic endometrium without atypia is necessary.
KW - angiogenesis
KW - endometrial hyperplasia
KW - endometrial vascularization
KW - ГИПЕРПЛАЗИЯ ЭНДОМЕТРИЯ
KW - ВАСКУЛЯРИЗАЦИЯ ЭНДОМЕТРИЯ
KW - АНГИОГЕНЕЗ
UR - https://www.scopus.com/pages/publications/105025985663
UR - https://www.elibrary.ru/item.asp?id=84086460
UR - https://www.mendeley.com/catalogue/c0f80ea3-8e17-3b19-a8ea-952c43413e1d/
U2 - 10.17116/patol20258706128
DO - 10.17116/patol20258706128
M3 - Article
C2 - 41328464
VL - 87
SP - 28
EP - 33
JO - Arkhiv Patologii
JF - Arkhiv Patologii
SN - 0004-1955
IS - 6
M1 - 4
ER -
ID: 74323657