Research output: Contribution to journal › Article › peer-review
Elemental Boron Nanoparticles : Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. / Uspenskii, S. A.; Khaptakhanova, P. A.; Zaboronok, A. A. et al.
In: Doklady Chemistry, Vol. 491, No. 1, 01.03.2020, p. 45-48.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Elemental Boron Nanoparticles
T2 - Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy
AU - Uspenskii, S. A.
AU - Khaptakhanova, P. A.
AU - Zaboronok, A. A.
AU - Kurkin, T. S.
AU - Volkova, O. Yu
AU - Mechetina, L. V.
AU - Taranin, A. V.
AU - Kanygin, V. V.
AU - Akira, Matsumura
AU - Taskaev, S. Yu
N1 - Publisher Copyright: © 2020, Pleiades Publishing, Ltd. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.
AB - A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.
KW - boron nanoparticles
KW - boron neutron capture therapy
KW - cavitation
KW - cytotoxicity
KW - elemental boron
KW - epithermal neutron accelerator
KW - glioma
KW - ultrasonic dispersion
UR - http://www.scopus.com/inward/record.url?scp=85088571327&partnerID=8YFLogxK
U2 - 10.1134/S0012500820030027
DO - 10.1134/S0012500820030027
M3 - Article
AN - SCOPUS:85088571327
VL - 491
SP - 45
EP - 48
JO - Doklady Chemistry
JF - Doklady Chemistry
SN - 0012-5008
IS - 1
ER -
ID: 24833854