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Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity. / Gurskaya, Larisa; Politanskaya, Larisa; Wang, Jiaying et al.

In: Journal of Fluorine Chemistry, Vol. 274, 110240, 02.2024.

Research output: Contribution to journal › Article › peer-review

Harvard

Gurskaya, L, Politanskaya, L, Wang, J, Ilyina, P, Volobueva, A & Zarubaev, V 2024, 'Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity', Journal of Fluorine Chemistry, vol. 274, 110240. https://doi.org/10.1016/j.jfluchem.2024.110240

APA

Gurskaya, L., Politanskaya, L., Wang, J., Ilyina, P., Volobueva, A., & Zarubaev, V. (2024). Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity. Journal of Fluorine Chemistry, 274, [110240]. https://doi.org/10.1016/j.jfluchem.2024.110240

Vancouver

Gurskaya L, Politanskaya L, Wang J, Ilyina P, Volobueva A, Zarubaev V. Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity. Journal of Fluorine Chemistry. 2024 Feb;274:110240. doi: 10.1016/j.jfluchem.2024.110240

Author

Gurskaya, Larisa ; Politanskaya, Larisa ; Wang, Jiaying et al. / Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity. In: Journal of Fluorine Chemistry. 2024 ; Vol. 274.

BibTeX

@article{7736c36bb524437ab9234efc94ccf594,
title = "Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity",
abstract = "A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).",
keywords = "Aryl isocyanates, Fluorinated 2-amino-1,1′-biphenyls, Influenza virus, Trifluoromethanesulfonic acid",
author = "Larisa Gurskaya and Larisa Politanskaya and Jiaying Wang and Polina Ilyina and Alexandrina Volobueva and Vladimir Zarubaev",
note = "This work was supported by the Ministry of Science and Higher Education of the Russian Federation (project FWUE-2022-0002). Viro logical part of the study was supported by the State Task АААА-А21-121030200272-6 from Mar 02, 2021. Authors would like to acknowledge the Multi-Access Chemical Service Center SB RAS for spectral and analytical measurements. ",
year = "2024",
month = feb,
doi = "10.1016/j.jfluchem.2024.110240",
language = "English",
volume = "274",
journal = "Journal of Fluorine Chemistry",
issn = "0022-1139",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Efficient synthesis of novel fluorinated phenanthridin-6(5H)-one derivatives and in vitro evaluation of their antiviral activity

AU - Gurskaya, Larisa

AU - Politanskaya, Larisa

AU - Wang, Jiaying

AU - Ilyina, Polina

AU - Volobueva, Alexandrina

AU - Zarubaev, Vladimir

N1 - This work was supported by the Ministry of Science and Higher Education of the Russian Federation (project FWUE-2022-0002). Viro logical part of the study was supported by the State Task АААА-А21-121030200272-6 from Mar 02, 2021. Authors would like to acknowledge the Multi-Access Chemical Service Center SB RAS for spectral and analytical measurements.

PY - 2024/2

Y1 - 2024/2

N2 - A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).

AB - A convenient and efficient method for the synthesis of fluorinated phenanthridin-6(5H)-ones from the corresponding 2-isocyanato-1,1′-biphenyls mediated by trifluoromethanesulfonic acid in chlorobenzene is described. The reaction uses readily available starting materials, takes place under very mild reaction conditions (r. t.) and provides access to biologically promising fluorinated heterocycles in good to excellent yields. Synthesized compounds were tested in vitro for cytotoxicity in MDCK cell line and for antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1).

KW - Aryl isocyanates

KW - Fluorinated 2-amino-1,1′-biphenyls

KW - Influenza virus

KW - Trifluoromethanesulfonic acid

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85182884866&origin=inward&txGid=463ba69cc1dba068182e54852c27ede1

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001155807600001

UR - https://www.mendeley.com/catalogue/fc05c80e-98d5-32c9-86cd-84da3c9bda98/

U2 - 10.1016/j.jfluchem.2024.110240

DO - 10.1016/j.jfluchem.2024.110240

M3 - Article

VL - 274

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

SN - 0022-1139

M1 - 110240

ER -

ID: 61183141