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Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. / Potter, Ekaterina A.; Proskurina, Anastasia S.; Ritter, Genrikh S. et al.

In: Oncotarget, Vol. 9, No. 47, 19.06.2018, p. 28486-28499.

Research output: Contribution to journal › Article › peer-review

Harvard

Potter, EA, Proskurina, AS, Ritter, GS, Dolgova, EV, Nikolin, VP, Popova, NA, Taranov, OS, Efremov, YR, Bayborodin, SI, Ostanin, AA, Chernykh, ER, Kolchanov, NA & Bogachev, SS 2018, 'Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma', Oncotarget, vol. 9, no. 47, pp. 28486-28499. https://doi.org/10.18632/oncotarget.25503

APA

Potter, E. A., Proskurina, A. S., Ritter, G. S., Dolgova, E. V., Nikolin, V. P., Popova, N. A., Taranov, O. S., Efremov, Y. R., Bayborodin, S. I., Ostanin, A. A., Chernykh, E. R., Kolchanov, N. A., & Bogachev, S. S. (2018). Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. Oncotarget, 9(47), 28486-28499. https://doi.org/10.18632/oncotarget.25503

Vancouver

Potter EA, Proskurina AS, Ritter GS, Dolgova EV, Nikolin VP, Popova NA et al. Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. Oncotarget. 2018 Jun 19;9(47):28486-28499. doi: 10.18632/oncotarget.25503

Author

Potter, Ekaterina A. ; Proskurina, Anastasia S. ; Ritter, Genrikh S. et al. / Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. In: Oncotarget. 2018 ; Vol. 9, No. 47. pp. 28486-28499.

BibTeX

@article{f99b8d54109442019614955584fb71cf,
title = "Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma",
abstract = "Krebs-2 solid carcinoma was cured using a new {"}3+1{"} strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the {"}winter repair cycle{"} (November- April), is completely eliminated in the summer period (June-September). We conclude that ?ne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy.",
keywords = "Cyclophosphamide, DNA internalization, Repair cycle, Seasonal cyclicity, Synchronization",
author = "Potter, {Ekaterina A.} and Proskurina, {Anastasia S.} and Ritter, {Genrikh S.} and Dolgova, {Evgenia V.} and Nikolin, {Valeriy P.} and Popova, {Nelly A.} and Taranov, {Oleg S.} and Efremov, {Yaroslav R.} and Bayborodin, {Sergey I.} and Ostanin, {Aleksandr A.} and Chernykh, {Elena R.} and Kolchanov, {Nikolay A.} and Bogachev, {Sergey S.}",
year = "2018",
month = jun,
day = "19",
doi = "10.18632/oncotarget.25503",
language = "English",
volume = "9",
pages = "28486--28499",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "47",

}

RIS

TY - JOUR

T1 - Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma

AU - Potter, Ekaterina A.

AU - Proskurina, Anastasia S.

AU - Ritter, Genrikh S.

AU - Dolgova, Evgenia V.

AU - Nikolin, Valeriy P.

AU - Popova, Nelly A.

AU - Taranov, Oleg S.

AU - Efremov, Yaroslav R.

AU - Bayborodin, Sergey I.

AU - Ostanin, Aleksandr A.

AU - Chernykh, Elena R.

AU - Kolchanov, Nikolay A.

AU - Bogachev, Sergey S.

PY - 2018/6/19

Y1 - 2018/6/19

N2 - Krebs-2 solid carcinoma was cured using a new "3+1" strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the "winter repair cycle" (November- April), is completely eliminated in the summer period (June-September). We conclude that ?ne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy.

AB - Krebs-2 solid carcinoma was cured using a new "3+1" strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the "winter repair cycle" (November- April), is completely eliminated in the summer period (June-September). We conclude that ?ne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy.

KW - Cyclophosphamide

KW - DNA internalization

KW - Repair cycle

KW - Seasonal cyclicity

KW - Synchronization

UR - http://www.scopus.com/inward/record.url?scp=85048766238&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.25503

DO - 10.18632/oncotarget.25503

M3 - Article

C2 - 29983875

AN - SCOPUS:85048766238

VL - 9

SP - 28486

EP - 28499

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 47

ER -

ID: 14101455