Effects of Sex and Group Size on Behavior and Brain Biogenic Amines in Short-Lived Turquoise Killifish (Nothobranchius furzeri)

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Effects of Sex and Group Size on Behavior and Brain Biogenic Amines in Short-Lived Turquoise Killifish (Nothobranchius furzeri). / Evsiukova, Valentina; Antonov, Egor; Kulikov, Alexander V.

In: Zebrafish, Vol. 18, No. 4, 08.2021, p. 265-273.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4d1f2732fe72452e977bd36c672224db,

title = "Effects of Sex and Group Size on Behavior and Brain Biogenic Amines in Short-Lived Turquoise Killifish (Nothobranchius furzeri)",

abstract = "Short-lived turquoise killifish (Nothobranchius furzeri) becomes a popular model species for neuroscience. However, the effects of sex and rearing conditions on behavior and brain monoamines in N. furzeri are unknown. In this article, we study the body mass, behavior in the novel tank diving test, levels of noradrenaline (NA), dopamine (DA), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) in the brain of 108 day-old N. furzeri males and females reared in small (one male and one or two females in 4-L tanks) and large (four males and four females in 25-L tanks) groups. Males were heavier and had a lower NA level in the brain compared with females. The behavior of males and females did not differ in the novel tank diving test. Their DA, 5-HT, DOPAC, and 5-HIAA levels in the brain did not differ too. Males from small groups spent more time near the tank's bottom. Rearing in small groups reduced the DA level in the female brain and the DOPAC level in female and male brains. However, group size did not affect body mass, 5-HT and 5-HIAA levels in the brain. Thus, group size is important for behavior and neuroscience studies of N. furzeri.",

keywords = "brain, monoamines, Nothobranchius furzeri, novel tank diving test, rearing conditions, sexual difference",

author = "Valentina Evsiukova and Egor Antonov and Kulikov, {Alexander V.}",

note = "Funding Information: The studies are supported by the budget project (No. 0259-2019-0002) and implemented using the equipment of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS, supported by the Ministry of Education and Science of Russia (Unique identifier of the project RFME-FI62119X0023). Publisher Copyright: {\textcopyright} 2021, Mary Ann Liebert, Inc., publishers.",

year = "2021",

month = aug,

doi = "10.1089/zeb.2021.0001",

language = "English",

volume = "18",

pages = "265--273",

journal = "Zebrafish",

issn = "1545-8547",

publisher = "Mary Ann Liebert Inc.",

number = "4",

}

RIS

TY - JOUR

T1 - Effects of Sex and Group Size on Behavior and Brain Biogenic Amines in Short-Lived Turquoise Killifish (Nothobranchius furzeri)

AU - Evsiukova, Valentina

AU - Antonov, Egor

AU - Kulikov, Alexander V.

N1 - Funding Information: The studies are supported by the budget project (No. 0259-2019-0002) and implemented using the equipment of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS, supported by the Ministry of Education and Science of Russia (Unique identifier of the project RFME-FI62119X0023). Publisher Copyright: © 2021, Mary Ann Liebert, Inc., publishers.

PY - 2021/8

Y1 - 2021/8

N2 - Short-lived turquoise killifish (Nothobranchius furzeri) becomes a popular model species for neuroscience. However, the effects of sex and rearing conditions on behavior and brain monoamines in N. furzeri are unknown. In this article, we study the body mass, behavior in the novel tank diving test, levels of noradrenaline (NA), dopamine (DA), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) in the brain of 108 day-old N. furzeri males and females reared in small (one male and one or two females in 4-L tanks) and large (four males and four females in 25-L tanks) groups. Males were heavier and had a lower NA level in the brain compared with females. The behavior of males and females did not differ in the novel tank diving test. Their DA, 5-HT, DOPAC, and 5-HIAA levels in the brain did not differ too. Males from small groups spent more time near the tank's bottom. Rearing in small groups reduced the DA level in the female brain and the DOPAC level in female and male brains. However, group size did not affect body mass, 5-HT and 5-HIAA levels in the brain. Thus, group size is important for behavior and neuroscience studies of N. furzeri.

AB - Short-lived turquoise killifish (Nothobranchius furzeri) becomes a popular model species for neuroscience. However, the effects of sex and rearing conditions on behavior and brain monoamines in N. furzeri are unknown. In this article, we study the body mass, behavior in the novel tank diving test, levels of noradrenaline (NA), dopamine (DA), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) in the brain of 108 day-old N. furzeri males and females reared in small (one male and one or two females in 4-L tanks) and large (four males and four females in 25-L tanks) groups. Males were heavier and had a lower NA level in the brain compared with females. The behavior of males and females did not differ in the novel tank diving test. Their DA, 5-HT, DOPAC, and 5-HIAA levels in the brain did not differ too. Males from small groups spent more time near the tank's bottom. Rearing in small groups reduced the DA level in the female brain and the DOPAC level in female and male brains. However, group size did not affect body mass, 5-HT and 5-HIAA levels in the brain. Thus, group size is important for behavior and neuroscience studies of N. furzeri.

KW - brain

KW - monoamines

KW - Nothobranchius furzeri

KW - novel tank diving test

KW - rearing conditions

KW - sexual difference

UR - http://www.scopus.com/inward/record.url?scp=85113404001&partnerID=8YFLogxK

U2 - 10.1089/zeb.2021.0001

DO - 10.1089/zeb.2021.0001

M3 - Article

C2 - 34324391

AN - SCOPUS:85113404001

VL - 18

SP - 265

EP - 273

JO - Zebrafish

JF - Zebrafish

SN - 1545-8547

IS - 4

ER -

ID: 34086316