Research output: Contribution to journal › Article › peer-review
Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats. / Igonina, Tatyana N.; Ragaeva, Diana S.; Petrova, Olga M. et al.
In: Hypertension in pregnancy, Vol. 38, No. 4, 02.10.2019, p. 208-216.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats
AU - Igonina, Tatyana N.
AU - Ragaeva, Diana S.
AU - Petrova, Olga M.
AU - Rozkova, Irina N.
AU - Brusentsev, Eugeny Yu
AU - Amstislavsky, Sergey Ya
PY - 2019/10/2
Y1 - 2019/10/2
N2 - Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female offspring. When ET was accompanied with in vitro culture in R1ECM, not only the female offspring, but also males demonstrated alleviation of hypertension. Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring.
AB - Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female offspring. When ET was accompanied with in vitro culture in R1ECM, not only the female offspring, but also males demonstrated alleviation of hypertension. Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring.
KW - culture
KW - blood pressure
KW - embryo transfer
KW - hypertensive rats
KW - offspring neurodevelopment
KW - In vitro culture
KW - SEX
KW - VASCULAR DYSFUNCTION
KW - BOVINE EMBRYOS
KW - FOLLOW-UP
KW - PRENATAL STRESS
KW - BLOOD-PRESSURE
KW - ASSISTED REPRODUCTION
KW - GENE-EXPRESSION
KW - REPRODUCTIVE TECHNOLOGIES
KW - GENDER-DIFFERENCES
UR - http://www.scopus.com/inward/record.url?scp=85072992693&partnerID=8YFLogxK
U2 - 10.1080/10641955.2019.1647232
DO - 10.1080/10641955.2019.1647232
M3 - Article
C2 - 31364410
AN - SCOPUS:85072992693
VL - 38
SP - 208
EP - 216
JO - Hypertension in pregnancy
JF - Hypertension in pregnancy
SN - 1525-6065
IS - 4
ER -
ID: 21859491