Research output: Contribution to journal › Article › peer-review
Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice : Sex-Specific Effects. / Bondar, Natalya P.; Lepeshko, Arina A.; Reshetnikov, Vasiliy V.
In: Behavioural Neurology, Vol. 2018, 1538931, 01.01.2018, p. 1538931.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice
T2 - Sex-Specific Effects
AU - Bondar, Natalya P.
AU - Lepeshko, Arina A.
AU - Reshetnikov, Vasiliy V.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.
AB - Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.
KW - Animals
KW - Animals, Newborn
KW - Anxiety/psychology
KW - Behavior, Animal/physiology
KW - Exploratory Behavior/physiology
KW - Female
KW - Male
KW - Maternal Deprivation
KW - Mice
KW - Motor Activity/physiology
KW - Sex Factors
KW - Social Behavior
KW - Stress, Psychological/psychology
KW - CHILDHOOD MALTREATMENT
KW - NEUROTROPHIC FACTOR
KW - CORTICOSTERONE SECRETION
KW - PREFRONTAL CORTEX
KW - MATERNAL SEPARATION
KW - GLUCOCORTICOID-RECEPTOR
KW - MESSENGER-RNA
KW - PLUS-MAZE
KW - GENDER-DIFFERENCES
KW - ESTROUS-CYCLE
UR - http://www.scopus.com/inward/record.url?scp=85042665323&partnerID=8YFLogxK
U2 - 10.1155/2018/1538931
DO - 10.1155/2018/1538931
M3 - Article
C2 - 29619126
AN - SCOPUS:85042665323
VL - 2018
SP - 1538931
JO - Behavioural Neurology
JF - Behavioural Neurology
SN - 0953-4180
M1 - 1538931
ER -
ID: 12099809