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Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice : Sex-Specific Effects. / Bondar, Natalya P.; Lepeshko, Arina A.; Reshetnikov, Vasiliy V.

In: Behavioural Neurology, Vol. 2018, 1538931, 01.01.2018, p. 1538931.

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Harvard

Bondar, NP, Lepeshko, AA & Reshetnikov, VV 2018, 'Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects', Behavioural Neurology, vol. 2018, 1538931, pp. 1538931. https://doi.org/10.1155/2018/1538931

APA

Vancouver

Bondar NP, Lepeshko AA, Reshetnikov VV. Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects. Behavioural Neurology. 2018 Jan 1;2018:1538931. 1538931. doi: 10.1155/2018/1538931

Author

Bondar, Natalya P. ; Lepeshko, Arina A. ; Reshetnikov, Vasiliy V. / Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice : Sex-Specific Effects. In: Behavioural Neurology. 2018 ; Vol. 2018. pp. 1538931.

BibTeX

@article{c524ba8e89ed4bf99a057a5c485c55d0,
title = "Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects",
abstract = "Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.",
keywords = "Animals, Animals, Newborn, Anxiety/psychology, Behavior, Animal/physiology, Exploratory Behavior/physiology, Female, Male, Maternal Deprivation, Mice, Motor Activity/physiology, Sex Factors, Social Behavior, Stress, Psychological/psychology, CHILDHOOD MALTREATMENT, NEUROTROPHIC FACTOR, CORTICOSTERONE SECRETION, PREFRONTAL CORTEX, MATERNAL SEPARATION, GLUCOCORTICOID-RECEPTOR, MESSENGER-RNA, PLUS-MAZE, GENDER-DIFFERENCES, ESTROUS-CYCLE",
author = "Bondar, {Natalya P.} and Lepeshko, {Arina A.} and Reshetnikov, {Vasiliy V.}",
year = "2018",
month = jan,
day = "1",
doi = "10.1155/2018/1538931",
language = "English",
volume = "2018",
pages = "1538931",
journal = "Behavioural Neurology",
issn = "0953-4180",
publisher = "Hindawi Limited",

}

RIS

TY - JOUR

T1 - Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice

T2 - Sex-Specific Effects

AU - Bondar, Natalya P.

AU - Lepeshko, Arina A.

AU - Reshetnikov, Vasiliy V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.

AB - Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.

KW - Animals

KW - Animals, Newborn

KW - Anxiety/psychology

KW - Behavior, Animal/physiology

KW - Exploratory Behavior/physiology

KW - Female

KW - Male

KW - Maternal Deprivation

KW - Mice

KW - Motor Activity/physiology

KW - Sex Factors

KW - Social Behavior

KW - Stress, Psychological/psychology

KW - CHILDHOOD MALTREATMENT

KW - NEUROTROPHIC FACTOR

KW - CORTICOSTERONE SECRETION

KW - PREFRONTAL CORTEX

KW - MATERNAL SEPARATION

KW - GLUCOCORTICOID-RECEPTOR

KW - MESSENGER-RNA

KW - PLUS-MAZE

KW - GENDER-DIFFERENCES

KW - ESTROUS-CYCLE

UR - http://www.scopus.com/inward/record.url?scp=85042665323&partnerID=8YFLogxK

U2 - 10.1155/2018/1538931

DO - 10.1155/2018/1538931

M3 - Article

C2 - 29619126

AN - SCOPUS:85042665323

VL - 2018

SP - 1538931

JO - Behavioural Neurology

JF - Behavioural Neurology

SN - 0953-4180

M1 - 1538931

ER -

ID: 12099809