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Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. / Yanshole, L. V.; Yanshole, V. V.; Snytnikova, O. A. et al.

In: Doklady Biochemistry and Biophysics, Vol. 464, No. 1, 21, 01.09.2015, p. 341-345.

Research output: Contribution to journal › Article › peer-review

Harvard

Yanshole, LV, Yanshole, VV, Snytnikova, OA, Fursova, AZ, Kolosova, NG, Tsentalovich, YP & Sagdeev, RZ 2015, 'Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin', Doklady Biochemistry and Biophysics, vol. 464, no. 1, 21, pp. 341-345. https://doi.org/10.1134/S1607672915050191

APA

Yanshole, L. V., Yanshole, V. V., Snytnikova, O. A., Fursova, A. Z., Kolosova, N. G., Tsentalovich, Y. P., & Sagdeev, R. Z. (2015). Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. Doklady Biochemistry and Biophysics, 464(1), 341-345. [21]. https://doi.org/10.1134/S1607672915050191

Vancouver

Yanshole LV, Yanshole VV, Snytnikova OA, Fursova AZ, Kolosova NG, Tsentalovich YP et al. Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. Doklady Biochemistry and Biophysics. 2015 Sept 1;464(1):341-345. 21. doi: 10.1134/S1607672915050191

Author

Yanshole, L. V. ; Yanshole, V. V. ; Snytnikova, O. A. et al. / Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. In: Doklady Biochemistry and Biophysics. 2015 ; Vol. 464, No. 1. pp. 341-345.

BibTeX

@article{5985c7b78fb44f14bf5be4237beda723,
title = "Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin",
abstract = "The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.",
author = "Yanshole, {L. V.} and Yanshole, {V. V.} and Snytnikova, {O. A.} and Fursova, {A. Zh} and Kolosova, {N. G.} and Tsentalovich, {Yu P.} and Sagdeev, {R. Z.}",
note = "Publisher Copyright: {\textcopyright} 2015, Pleiades Publishing, Ltd.",
year = "2015",
month = sep,
day = "1",
doi = "10.1134/S1607672915050191",
language = "English",
volume = "464",
pages = "341--345",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

AU - Yanshole, L. V.

AU - Yanshole, V. V.

AU - Snytnikova, O. A.

AU - Fursova, A. Zh

AU - Kolosova, N. G.

AU - Tsentalovich, Yu P.

AU - Sagdeev, R. Z.

N1 - Publisher Copyright: © 2015, Pleiades Publishing, Ltd.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

AB - The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

UR - http://www.scopus.com/inward/record.url?scp=84945576281&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=24967776

U2 - 10.1134/S1607672915050191

DO - 10.1134/S1607672915050191

M3 - Article

C2 - 26518564

AN - SCOPUS:84945576281

VL - 464

SP - 341

EP - 345

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

M1 - 21

ER -

ID: 34441285