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Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels. / Pravikova, P. D.; Lavrinenko, V.; Ivanova, L. N.

In: Bulletin of Experimental Biology and Medicine, Vol. 167, No. 2, 15.06.2019, p. 233-236.

Research output: Contribution to journal › Article › peer-review

Harvard

Pravikova, PD, Lavrinenko, V & Ivanova, LN 2019, 'Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels', Bulletin of Experimental Biology and Medicine, vol. 167, no. 2, pp. 233-236. https://doi.org/10.1007/s10517-019-04498-w

APA

Pravikova, P. D., Lavrinenko, V., & Ivanova, L. N. (2019). Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels. Bulletin of Experimental Biology and Medicine, 167(2), 233-236. https://doi.org/10.1007/s10517-019-04498-w

Vancouver

Pravikova PD, Lavrinenko V, Ivanova LN. Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels. Bulletin of Experimental Biology and Medicine. 2019 Jun 15;167(2):233-236. doi: 10.1007/s10517-019-04498-w

Author

Pravikova, P. D. ; Lavrinenko, V. ; Ivanova, L. N. / Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels. In: Bulletin of Experimental Biology and Medicine. 2019 ; Vol. 167, No. 2. pp. 233-236.

BibTeX

@article{5efa9d3e236342ce9b9d0b42688ef192,
title = "Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels",
abstract = "We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.",
keywords = "concentrating function, hyaluronan, kidney, nitric oxide, vasopressin",
author = "Pravikova, {P. D.} and V. Lavrinenko and Ivanova, {L. N.}",
year = "2019",
month = jun,
day = "15",
doi = "10.1007/s10517-019-04498-w",
language = "English",
volume = "167",
pages = "233--236",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels

AU - Pravikova, P. D.

AU - Lavrinenko, V.

AU - Ivanova, L. N.

PY - 2019/6/15

Y1 - 2019/6/15

N2 - We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.

AB - We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.

KW - concentrating function

KW - hyaluronan

KW - kidney

KW - nitric oxide

KW - vasopressin

UR - http://www.scopus.com/inward/record.url?scp=85068024947&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04498-w

DO - 10.1007/s10517-019-04498-w

M3 - Article

C2 - 31236886

AN - SCOPUS:85068024947

VL - 167

SP - 233

EP - 236

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -

ID: 20710851