Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models

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Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models. / Sen'kova, Aleksandra V.; Bishani, Ali; Savin, Innokenty A. et al.

In: Biochimie, Vol. 229, 02.2025, p. 9-18.

Research output: Contribution to journal › Article › peer-review

Author

Sen'kova, Aleksandra V. ; Bishani, Ali ; Savin, Innokenty A. et al. / Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models. In: Biochimie. 2025 ; Vol. 229. pp. 9-18.

BibTeX

@article{2a77a003e6c74e938346f18f466bbef2,

title = "Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models",

abstract = "Previously, we described a 19-base pair double-stranded RNA with 3′-trinucleotide overhangs, acting as immunostimulatory RNA (isRNA). This molecule demonstrated notable antiproliferative effects on cancer cells, inhibited tumor growth, and elicited immunostimulatory and antiviral responses by inducing cytokine and interferon production. Within this study, we compared the efficiency of lung fibrosis development, initiated in mice by BLM or LPS using different schemes of induction. Then we compared the effect of isRNA used in a preventive or therapeutic regimen on the development of fibrosis in selected BLM- and LPS-induced mouse models and showed that isRNA can be used in pathological conditions accompanied by the development of inflammation and the risk of fibrosis formation, without adverse side effects. Prophylactic regimen of isRNA application is beneficial for prevention of the development of pulmonary fibrosis.",

keywords = "Bleomycine, Immunostimulatory RNA, Inflammation, LPS, Pulmonary fibrosis, Mice, Inbred C57BL, Lipopolysaccharides/pharmacology, Animals, Adjuvants, Immunologic/pharmacology, Female, Mice, RNA, Double-Stranded, Bleomycin/adverse effects, Pulmonary Fibrosis/chemically induced, Disease Models, Animal",

author = "Sen'kova, {Aleksandra V.} and Ali Bishani and Savin, {Innokenty A.} and Zenkova, {Marina A.} and Chernolovskaya, {Elena L.}",

note = "This research was funded by the Russian Science Foundation (grant #19-74-30011) and project ICBFM SB RAS #121031300044-5 Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models / A. V. Sen'kova, A. Bishani, I. A. Savin [et al.] // Biochimie. – 2024. – DOI 10.1016/j.biochi.2024.09.016.",

year = "2025",

month = feb,

doi = "10.1016/j.biochi.2024.09.016",

language = "English",

volume = "229",

pages = "9--18",

journal = "Biochimie",

issn = "0300-9084",

publisher = "Elsevier Science Publishing Company, Inc.",

}

RIS

TY - JOUR

T1 - Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models

AU - Sen'kova, Aleksandra V.

AU - Bishani, Ali

AU - Savin, Innokenty A.

AU - Zenkova, Marina A.

AU - Chernolovskaya, Elena L.

N1 - This research was funded by the Russian Science Foundation (grant #19-74-30011) and project ICBFM SB RAS #121031300044-5 Effect of immunostimulatory RNA on the fibrosis development in Bleomycin- or LPS-induced mouse models / A. V. Sen'kova, A. Bishani, I. A. Savin [et al.] // Biochimie. – 2024. – DOI 10.1016/j.biochi.2024.09.016.

PY - 2025/2

Y1 - 2025/2

N2 - Previously, we described a 19-base pair double-stranded RNA with 3′-trinucleotide overhangs, acting as immunostimulatory RNA (isRNA). This molecule demonstrated notable antiproliferative effects on cancer cells, inhibited tumor growth, and elicited immunostimulatory and antiviral responses by inducing cytokine and interferon production. Within this study, we compared the efficiency of lung fibrosis development, initiated in mice by BLM or LPS using different schemes of induction. Then we compared the effect of isRNA used in a preventive or therapeutic regimen on the development of fibrosis in selected BLM- and LPS-induced mouse models and showed that isRNA can be used in pathological conditions accompanied by the development of inflammation and the risk of fibrosis formation, without adverse side effects. Prophylactic regimen of isRNA application is beneficial for prevention of the development of pulmonary fibrosis.

AB - Previously, we described a 19-base pair double-stranded RNA with 3′-trinucleotide overhangs, acting as immunostimulatory RNA (isRNA). This molecule demonstrated notable antiproliferative effects on cancer cells, inhibited tumor growth, and elicited immunostimulatory and antiviral responses by inducing cytokine and interferon production. Within this study, we compared the efficiency of lung fibrosis development, initiated in mice by BLM or LPS using different schemes of induction. Then we compared the effect of isRNA used in a preventive or therapeutic regimen on the development of fibrosis in selected BLM- and LPS-induced mouse models and showed that isRNA can be used in pathological conditions accompanied by the development of inflammation and the risk of fibrosis formation, without adverse side effects. Prophylactic regimen of isRNA application is beneficial for prevention of the development of pulmonary fibrosis.

KW - Bleomycine

KW - Immunostimulatory RNA

KW - Inflammation

KW - LPS

KW - Pulmonary fibrosis

KW - Mice, Inbred C57BL

KW - Lipopolysaccharides/pharmacology

KW - Animals

KW - Adjuvants, Immunologic/pharmacology

KW - Female

KW - Mice

KW - RNA, Double-Stranded

KW - Bleomycin/adverse effects

KW - Pulmonary Fibrosis/chemically induced

KW - Disease Models, Animal

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85205718105&origin=inward&txGid=7ec1d3fdd9e78dc5ea0933c31c88622b

UR - https://www.mendeley.com/catalogue/b132eef3-d601-34b7-bf27-38e7b06a1236/

UR - https://pubmed.ncbi.nlm.nih.gov/39362399/

UR - https://elibrary.ru/item.asp?id=74728626

U2 - 10.1016/j.biochi.2024.09.016

DO - 10.1016/j.biochi.2024.09.016

M3 - Article

C2 - 39362399

VL - 229

SP - 9

EP - 18

JO - Biochimie

JF - Biochimie

SN - 0300-9084

ER -

ID: 61307746