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Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. / Privodnova, Evgeniya Yu; Volf, Nina V.

Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022. Institute of Electrical and Electronics Engineers Inc., 2022. p. 200-204 (Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022).

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Harvard

Privodnova, EY & Volf, NV 2022, Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. in Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022. Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022, Institute of Electrical and Electronics Engineers Inc., pp. 200-204, 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022, Novosibirsk, Russian Federation, 07.07.2022. https://doi.org/10.1109/CSGB56354.2022.9865351

APA

Privodnova, E. Y., & Volf, N. V. (2022). Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. In Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022 (pp. 200-204). (Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSGB56354.2022.9865351

Vancouver

Privodnova EY, Volf NV. Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. In Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022. Institute of Electrical and Electronics Engineers Inc. 2022. p. 200-204. (Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022). doi: 10.1109/CSGB56354.2022.9865351

Author

Privodnova, Evgeniya Yu ; Volf, Nina V. / Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022. Institute of Electrical and Electronics Engineers Inc., 2022. pp. 200-204 (Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022).

BibTeX

@inproceedings{f1ba9e67e080455b812141f4ad91cb7a,
title = "Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism",
abstract = "Main functions of brain-derived neurotrophic factor (BDNF) are neuroprotection and synaptic plasticity. A common single nucleotide polymorphism in the human BDNF gene (Val66Met) impairs activity-dependent secretion of the BDNF, and carrying Met allele is associated with poorer learning. We explored the role of BDNF polymorphism in short-term plasticity induced by complex cognitive stimulation with creativity thinking tasks in Caucasian adults from younger (22.7±3.7 years old, N = 63) and older (63.5±5.2 years old, N = 49) age groups. Resting-state EEG with eyes open was recorded prior to and immediately after forty-minute verbal and figural creative task performance. The EEG spectral density in individual alpha frequency band was calculated using FFT in pre-task and post-task intervals. All subjects were genotyped for BDNF status. ANOVA revealed more left-sided (left>right) changes from pre-task to post-task intervals in Val/Val homozygotes in comparison with Met carriers. BDNF-associated alpha power asymmetry indicator in frontal region, which is well-known manifestation of motivational withdrawal/approach, was strongly correlated with interest in tasks (not with originality, amount of ideas, or task difficulty). Mediation analysis confirmed that attenuated frontal asymmetry (left-right) of pre/post task changes in Met carriers in comparison to Val/Val was associated with lower interest in tasks - component of internal motivation for creative problem solving. These findings suggest that complex cognitive stimulation with creativity tasks induced tendency towards withdrawal motivation in Met carriers in comparison to Val/Val at the level of brain activity.",
keywords = "alpha power, BDNF Val66Met polymorphism, brain-derived neurotrophic factor (BDNF), hemispheric asymmetry, short-term plasticity, withdrawal/approach",
author = "Privodnova, {Evgeniya Yu} and Volf, {Nina V.}",
note = "Funding Information: The study was supported by budgetary funding for basic scientific research (theme No. 122042700001-9). Publisher Copyright: {\textcopyright} 2022 IEEE.; 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022 ; Conference date: 07-07-2022 Through 08-07-2022",
year = "2022",
doi = "10.1109/CSGB56354.2022.9865351",
language = "English",
series = "Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "200--204",
booktitle = "Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022",
address = "United States",

}

RIS

TY - GEN

T1 - Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism

AU - Privodnova, Evgeniya Yu

AU - Volf, Nina V.

N1 - Funding Information: The study was supported by budgetary funding for basic scientific research (theme No. 122042700001-9). Publisher Copyright: © 2022 IEEE.

PY - 2022

Y1 - 2022

N2 - Main functions of brain-derived neurotrophic factor (BDNF) are neuroprotection and synaptic plasticity. A common single nucleotide polymorphism in the human BDNF gene (Val66Met) impairs activity-dependent secretion of the BDNF, and carrying Met allele is associated with poorer learning. We explored the role of BDNF polymorphism in short-term plasticity induced by complex cognitive stimulation with creativity thinking tasks in Caucasian adults from younger (22.7±3.7 years old, N = 63) and older (63.5±5.2 years old, N = 49) age groups. Resting-state EEG with eyes open was recorded prior to and immediately after forty-minute verbal and figural creative task performance. The EEG spectral density in individual alpha frequency band was calculated using FFT in pre-task and post-task intervals. All subjects were genotyped for BDNF status. ANOVA revealed more left-sided (left>right) changes from pre-task to post-task intervals in Val/Val homozygotes in comparison with Met carriers. BDNF-associated alpha power asymmetry indicator in frontal region, which is well-known manifestation of motivational withdrawal/approach, was strongly correlated with interest in tasks (not with originality, amount of ideas, or task difficulty). Mediation analysis confirmed that attenuated frontal asymmetry (left-right) of pre/post task changes in Met carriers in comparison to Val/Val was associated with lower interest in tasks - component of internal motivation for creative problem solving. These findings suggest that complex cognitive stimulation with creativity tasks induced tendency towards withdrawal motivation in Met carriers in comparison to Val/Val at the level of brain activity.

AB - Main functions of brain-derived neurotrophic factor (BDNF) are neuroprotection and synaptic plasticity. A common single nucleotide polymorphism in the human BDNF gene (Val66Met) impairs activity-dependent secretion of the BDNF, and carrying Met allele is associated with poorer learning. We explored the role of BDNF polymorphism in short-term plasticity induced by complex cognitive stimulation with creativity thinking tasks in Caucasian adults from younger (22.7±3.7 years old, N = 63) and older (63.5±5.2 years old, N = 49) age groups. Resting-state EEG with eyes open was recorded prior to and immediately after forty-minute verbal and figural creative task performance. The EEG spectral density in individual alpha frequency band was calculated using FFT in pre-task and post-task intervals. All subjects were genotyped for BDNF status. ANOVA revealed more left-sided (left>right) changes from pre-task to post-task intervals in Val/Val homozygotes in comparison with Met carriers. BDNF-associated alpha power asymmetry indicator in frontal region, which is well-known manifestation of motivational withdrawal/approach, was strongly correlated with interest in tasks (not with originality, amount of ideas, or task difficulty). Mediation analysis confirmed that attenuated frontal asymmetry (left-right) of pre/post task changes in Met carriers in comparison to Val/Val was associated with lower interest in tasks - component of internal motivation for creative problem solving. These findings suggest that complex cognitive stimulation with creativity tasks induced tendency towards withdrawal motivation in Met carriers in comparison to Val/Val at the level of brain activity.

KW - alpha power

KW - BDNF Val66Met polymorphism

KW - brain-derived neurotrophic factor (BDNF)

KW - hemispheric asymmetry

KW - short-term plasticity

KW - withdrawal/approach

UR - http://www.scopus.com/inward/record.url?scp=85138467593&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/9e9011ef-586b-30ed-97b4-3001cf7e0db6/

U2 - 10.1109/CSGB56354.2022.9865351

DO - 10.1109/CSGB56354.2022.9865351

M3 - Conference contribution

AN - SCOPUS:85138467593

T3 - Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022

SP - 200

EP - 204

BT - Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022

Y2 - 7 July 2022 through 8 July 2022

ER -

ID: 38034469