Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism. / Privodnova, Evgeniya Yu; Volf, Nina V.
Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022. Institute of Electrical and Electronics Engineers Inc., 2022. p. 200-204 (Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
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TY - GEN
T1 - Effect of Cognitive Stimulation with Creativity Tasks on Resting-State EEG Alpha Power Depends on BDNF Val66Met Polymorphism
AU - Privodnova, Evgeniya Yu
AU - Volf, Nina V.
N1 - Funding Information: The study was supported by budgetary funding for basic scientific research (theme No. 122042700001-9). Publisher Copyright: © 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Main functions of brain-derived neurotrophic factor (BDNF) are neuroprotection and synaptic plasticity. A common single nucleotide polymorphism in the human BDNF gene (Val66Met) impairs activity-dependent secretion of the BDNF, and carrying Met allele is associated with poorer learning. We explored the role of BDNF polymorphism in short-term plasticity induced by complex cognitive stimulation with creativity thinking tasks in Caucasian adults from younger (22.7±3.7 years old, N = 63) and older (63.5±5.2 years old, N = 49) age groups. Resting-state EEG with eyes open was recorded prior to and immediately after forty-minute verbal and figural creative task performance. The EEG spectral density in individual alpha frequency band was calculated using FFT in pre-task and post-task intervals. All subjects were genotyped for BDNF status. ANOVA revealed more left-sided (left>right) changes from pre-task to post-task intervals in Val/Val homozygotes in comparison with Met carriers. BDNF-associated alpha power asymmetry indicator in frontal region, which is well-known manifestation of motivational withdrawal/approach, was strongly correlated with interest in tasks (not with originality, amount of ideas, or task difficulty). Mediation analysis confirmed that attenuated frontal asymmetry (left-right) of pre/post task changes in Met carriers in comparison to Val/Val was associated with lower interest in tasks - component of internal motivation for creative problem solving. These findings suggest that complex cognitive stimulation with creativity tasks induced tendency towards withdrawal motivation in Met carriers in comparison to Val/Val at the level of brain activity.
AB - Main functions of brain-derived neurotrophic factor (BDNF) are neuroprotection and synaptic plasticity. A common single nucleotide polymorphism in the human BDNF gene (Val66Met) impairs activity-dependent secretion of the BDNF, and carrying Met allele is associated with poorer learning. We explored the role of BDNF polymorphism in short-term plasticity induced by complex cognitive stimulation with creativity thinking tasks in Caucasian adults from younger (22.7±3.7 years old, N = 63) and older (63.5±5.2 years old, N = 49) age groups. Resting-state EEG with eyes open was recorded prior to and immediately after forty-minute verbal and figural creative task performance. The EEG spectral density in individual alpha frequency band was calculated using FFT in pre-task and post-task intervals. All subjects were genotyped for BDNF status. ANOVA revealed more left-sided (left>right) changes from pre-task to post-task intervals in Val/Val homozygotes in comparison with Met carriers. BDNF-associated alpha power asymmetry indicator in frontal region, which is well-known manifestation of motivational withdrawal/approach, was strongly correlated with interest in tasks (not with originality, amount of ideas, or task difficulty). Mediation analysis confirmed that attenuated frontal asymmetry (left-right) of pre/post task changes in Met carriers in comparison to Val/Val was associated with lower interest in tasks - component of internal motivation for creative problem solving. These findings suggest that complex cognitive stimulation with creativity tasks induced tendency towards withdrawal motivation in Met carriers in comparison to Val/Val at the level of brain activity.
KW - alpha power
KW - BDNF Val66Met polymorphism
KW - brain-derived neurotrophic factor (BDNF)
KW - hemispheric asymmetry
KW - short-term plasticity
KW - withdrawal/approach
UR - http://www.scopus.com/inward/record.url?scp=85138467593&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9e9011ef-586b-30ed-97b4-3001cf7e0db6/
U2 - 10.1109/CSGB56354.2022.9865351
DO - 10.1109/CSGB56354.2022.9865351
M3 - Conference contribution
AN - SCOPUS:85138467593
T3 - Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022
SP - 200
EP - 204
BT - Proceedings - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2022
Y2 - 7 July 2022 through 8 July 2022
ER -
ID: 38034469