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Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells. / Chanyshev, M. D.; Koval, O. A.; Nushtaeva, A. A. et al.

In: Journal of Biochemical and Molecular Toxicology, Vol. 33, No. 6, e22314, 01.06.2019.

Research output: Contribution to journal › Article › peer-review

Harvard

Chanyshev, MD, Koval, OA, Nushtaeva, AA & Gulyaeva, LF 2019, 'Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells', Journal of Biochemical and Molecular Toxicology, vol. 33, no. 6, e22314. https://doi.org/10.1002/jbt.22314

APA

Chanyshev, M. D., Koval, O. A., Nushtaeva, A. A., & Gulyaeva, L. F. (2019). Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells. Journal of Biochemical and Molecular Toxicology, 33(6), [e22314]. https://doi.org/10.1002/jbt.22314

Vancouver

Chanyshev MD, Koval OA, Nushtaeva AA, Gulyaeva LF. Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells. Journal of Biochemical and Molecular Toxicology. 2019 Jun 1;33(6):e22314. Epub 2019 Feb 27. doi: 10.1002/jbt.22314

Author

Chanyshev, M. D. ; Koval, O. A. ; Nushtaeva, A. A. et al. / Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells. In: Journal of Biochemical and Molecular Toxicology. 2019 ; Vol. 33, No. 6.

BibTeX

@article{de494e7f454a49d08f46290f9e3e5c97,
title = "Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells",
abstract = "The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level. BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes. Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP. The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.",
keywords = "benzo[a]pyrene, endometrial primary cell culture, miR-126, miR-190a, target genes, CANCER-CELLS, APOPTOSIS, ANGIOGENESIS, CYCLE ARREST, DEGRADATION, MICRORNAS, DOMAIN 7",
author = "Chanyshev, {M. D.} and Koval, {O. A.} and Nushtaeva, {A. A.} and Gulyaeva, {L. F.}",
note = "{\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = jun,
day = "1",
doi = "10.1002/jbt.22314",
language = "English",
volume = "33",
journal = "Journal of Biochemical and Molecular Toxicology",
issn = "1095-6670",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

AU - Chanyshev, M. D.

AU - Koval, O. A.

AU - Nushtaeva, A. A.

AU - Gulyaeva, L. F.

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level. BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes. Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP. The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.

AB - The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level. BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes. Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP. The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.

KW - benzo[a]pyrene

KW - endometrial primary cell culture

KW - miR-126

KW - miR-190a

KW - target genes

KW - CANCER-CELLS

KW - APOPTOSIS

KW - ANGIOGENESIS

KW - CYCLE ARREST

KW - DEGRADATION

KW - MICRORNAS

KW - DOMAIN 7

UR - http://www.scopus.com/inward/record.url?scp=85062354374&partnerID=8YFLogxK

U2 - 10.1002/jbt.22314

DO - 10.1002/jbt.22314

M3 - Article

C2 - 30811740

AN - SCOPUS:85062354374

VL - 33

JO - Journal of Biochemical and Molecular Toxicology

JF - Journal of Biochemical and Molecular Toxicology

SN - 1095-6670

IS - 6

M1 - e22314

ER -

ID: 18680560